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Fukuma N, Kato K, Munakata K, et al. Baroreflex mechanisms and response to exercise in patients with heart disease. Clin Physiol Funct Imaging. 2012;32(4):305-9doi: 10.1111/j.1475-097X.2012.01127.x.
Fukuma, N., Kato, K., Munakata, K., Hayashi, H., Kato, Y., Aisu, N., Takahashi, H., Mabuchi, K., & Mizuno, K. (2012). Baroreflex mechanisms and response to exercise in patients with heart disease. Clinical physiology and functional imaging, 32(4), 305-9. https://doi.org/10.1111/j.1475-097X.2012.01127.x
Fukuma, Nagaharu, et al. "Baroreflex mechanisms and response to exercise in patients with heart disease." Clinical physiology and functional imaging vol. 32,4 (2012): 305-9. doi: https://doi.org/10.1111/j.1475-097X.2012.01127.x
Fukuma N, Kato K, Munakata K, Hayashi H, Kato Y, Aisu N, Takahashi H, Mabuchi K, Mizuno K. Baroreflex mechanisms and response to exercise in patients with heart disease. Clin Physiol Funct Imaging. 2012 Jul;32(4):305-9. doi: 10.1111/j.1475-097X.2012.01127.x. Epub 2012 Mar 26. PMID: 22681608; PMCID: PMC3440573.
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Clin Physiol Funct Imaging. 2012 Jul;32(4):305-9. doi: 10.1111/j.1475-097X.2012.01127.x. Epub 2012 Mar 26.

Baroreflex mechanisms and response to exercise in patients with heart disease.

Clinical physiology and functional imaging

Nagaharu Fukuma, Kazuyo Kato, Kazuo Munakata, Hiroko Hayashi, Yuko Kato, Noriko Aisu, Hiroshi Takahashi, Kousuke Mabuchi, Kyoichi Mizuno

Affiliations

  1. Cardiology Department of internal medicine, Nippon Medical School, Tokyo, Japan. [email protected]

PMID: 22681608 PMCID: PMC3440573 DOI: 10.1111/j.1475-097X.2012.01127.x

Abstract

BACKGROUND: Past reports showed that the baroreflex continuously regulates hemodynamics during exercise. However, it is still clinically unclear. If baroreflex mechanism is able to influence actually exercise cardiovascular control, baroreflex sympathetic and/or parasympathetic function relates to response to exercise. Therefore, we examined the relationship of heat rate changes to both blood pressure increment and decrement with tolerance and chronotropic response to peak exercise in patients with heart disease.

METHODS: In 25 male heart disease patients (60 ± 9 years) without decompensated heart failure, baroreceptor reflex sensitivity (BRS ms mmHg(-1) ) was measured by reflex heart rate responses to changes in blood pressure after phenylephrine (P-BRS) and nitroglycerin (N-BRS) injection, respectively. Symptom-limited treadmill exercise test was performed according to Bruce's protocol.

RESULTS: (i) The absolute values of blood pressure change after the administrations were similar between the agents because the dosages of nitroglycerin and phenylephrine were set to equalize absolute changes in blood pressure. (ii) In this study population, the ratio of N-BRS to P-BRS was not significantly correlated with hypertension and diabetes mellitus. (iii) Exercise capacity (METs) (r= -0.626) and heart rate response to exercise per METs (r=0.670) was significantly related to N-BRS but not to P-BRS.

CONCLUSION: We found that the abnormality of baroreflex function in the presence of blood pressure decrements can lead to insufficient capacity and easy sympathetic activation during exercise.

© 2012 The Authors Clinical Physiology and Functional Imaging © 2012 Scandinavian Society of Clinical Physiology and Nuclear Medicine.

References

  1. J Physiol. 1978 Jan;274:621-37 - PubMed
  2. Am J Physiol. 1993 Dec;265(6 Pt 2):H1928-38 - PubMed
  3. Circ Res. 1983 Mar;52(3):253-62 - PubMed
  4. J Appl Physiol (1985). 1990 Aug;69(2):407-18 - PubMed
  5. Circulation. 1989 Jan;79(1):83-92 - PubMed
  6. Circulation. 1991 Mar;83(3):945-52 - PubMed
  7. Am J Physiol. 1981 Dec;241(6):H838-49 - PubMed
  8. J Physiol. 2003 Apr 1;548(Pt 1):313-22 - PubMed
  9. Am J Cardiol. 1974 Dec;34(7):757-63 - PubMed
  10. Clin Cardiol. 1979 Feb;2(1):12-8 - PubMed
  11. Circulation. 1997 Oct 21;96(8):2586-94 - PubMed
  12. Int J Cardiol. 2004 Dec;97(3):503-8 - PubMed
  13. Circulation. 1996 Apr 15;93(8):1520-6 - PubMed
  14. Am J Physiol. 1989 Jan;256(1 Pt 2):H132-41 - PubMed
  15. Med Sci Sports Exerc. 1982;14(5):377-81 - PubMed
  16. J Physiol. 2002 Nov 1;544(3):939-48 - PubMed
  17. Lancet. 1998 Feb 14;351(9101):478-84 - PubMed
  18. J Am Coll Cardiol. 1983 Sep;2(3):411-7 - PubMed
  19. Am J Cardiol. 1992 Feb 15;69(5):523-31 - PubMed
  20. Am J Physiol. 1998 Dec;275(6):H2000-8 - PubMed
  21. J Physiol. 2003 Sep 15;551(Pt 3):1013-21 - PubMed
  22. Circ Res. 1969 Jan;24(1):109-21 - PubMed

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