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Fan XJ, Cao EH, Chi SJ, et al. Study on enhancement of tumor-killing effect and formation of new fluorophore in tumor cells. Proc Chin Acad Med Sci Peking Union Med Coll. 1990;5(2):107-11
Fan, X. J., Cao, E. H., Chi, S. J., & Wang, Y. X. (1990). Study on enhancement of tumor-killing effect and formation of new fluorophore in tumor cells. Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao, 5(2), 107-11.
Fan, X J, et al. "Study on enhancement of tumor-killing effect and formation of new fluorophore in tumor cells." Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao vol. 5,2 (1990): 107-11.
Fan XJ, Cao EH, Chi SJ, Wang YX. Study on enhancement of tumor-killing effect and formation of new fluorophore in tumor cells. Proc Chin Acad Med Sci Peking Union Med Coll. 1990;5(2):107-11. PMID: 2147061.
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Proc Chin Acad Med Sci Peking Union Med Coll. 1990;5(2):107-11.

Study on enhancement of tumor-killing effect and formation of new fluorophore in tumor cells.

Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao

X J Fan, E H Cao, S J Chi, Y X Wang

Affiliations

  1. Cancer Institute, CAMS, Beijing.

PMID: 2147061

Abstract

Hyperthermia (42-44 degrees C) and photosensitizing therapy can destroy S180 tumor cells, reduce malignant ascites and prolong the survival times of mice with carcinomas. The highest curative effect was observed when using a combination of the two treatments. Heating to 44 degrees C has a greater destructive effect on tumor cells than has heating to 42 degrees C. The results show that this is due to a synergistic interaction between these two treatments. The fluorescence spectrum of S180 cells was determined before and after treatment, and the indication was that the synergistic effect is probably related to a new fluorescence product; the greater the intensity of the new fluorescence, the more marked the synergy of hyperthermia and photosensitizing therapy. The maximum emission wavelength was 460nm (excitation wavelength 370nm).

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