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Nunez DJ, Davenport AP, Brown MJ. Atrial natriuretic factor mRNA and binding sites in the adrenal gland. Biochem J. 1990;271(2):555-8doi: 10.1042/bj2710555.
Nunez, D. J., Davenport, A. P., & Brown, M. J. (1990). Atrial natriuretic factor mRNA and binding sites in the adrenal gland. The Biochemical journal, 271(2), 555-8. https://doi.org/10.1042/bj2710555
Nunez, D J, et al. "Atrial natriuretic factor mRNA and binding sites in the adrenal gland." The Biochemical journal vol. 271,2 (1990): 555-8. doi: https://doi.org/10.1042/bj2710555
Nunez DJ, Davenport AP, Brown MJ. Atrial natriuretic factor mRNA and binding sites in the adrenal gland. Biochem J. 1990 Oct 15;271(2):555-8. doi: 10.1042/bj2710555. PMID: 2146954; PMCID: PMC1149591.
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Biochem J. 1990 Oct 15;271(2):555-8. doi: 10.1042/bj2710555.

Atrial natriuretic factor mRNA and binding sites in the adrenal gland.

The Biochemical journal

D J Nunez, A P Davenport, M J Brown

Affiliations

  1. Department of Medicine, University of Cambridge Clinical School, Addenbrooke's Hospital, U.K.

PMID: 2146954 PMCID: PMC1149591 DOI: 10.1042/bj2710555
Free PMC Article

Abstract

The factor inhibiting aldosterone secretion produced by the adrenal medulla may be atrial natriuretic factor (ANF), since the latter abolishes aldosterone release in response to a number of secretagogues, including angiotensin II and K+. In this study we have shown that cells in the adrenal medulla contain ANF mRNA and therefore have the potential to synthesize this peptide. The presence of binding sites for ANF predominantly in the adrenal zona glomerulosa suggests that, if ANF is synthesized in the medulla and transferred to the cortex, it may affect mineralocorticoid status.

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