Display options
Cite
Sowers MR, Wallace RB, Hollis BW. The relationship of 1,25-dihydroxyvitamin D and radial bone mass. Bone Miner. 1990;10(2):139-48doi: 10.1016/0169-6009(90)90089-x.
Sowers, M. R., Wallace, R. B., & Hollis, B. W. (1990). The relationship of 1,25-dihydroxyvitamin D and radial bone mass. Bone and mineral, 10(2), 139-48. https://doi.org/10.1016/0169-6009(90)90089-x
Sowers, M R, et al. "The relationship of 1,25-dihydroxyvitamin D and radial bone mass." Bone and mineral vol. 10,2 (1990): 139-48. doi: https://doi.org/10.1016/0169-6009(90)90089-x
Sowers MR, Wallace RB, Hollis BW. The relationship of 1,25-dihydroxyvitamin D and radial bone mass. Bone Miner. 1990 Aug;10(2):139-48. doi: 10.1016/0169-6009(90)90089-x. PMID: 2207393.
Copy Download .nbib Format: NLM
Share it on

Bone Miner. 1990 Aug;10(2):139-48. doi: 10.1016/0169-6009(90)90089-x.

The relationship of 1,25-dihydroxyvitamin D and radial bone mass.

Bone and mineral

M R Sowers, R B Wallace, B W Hollis

Affiliations

  1. Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor 48109.

PMID: 2207393 DOI: 10.1016/0169-6009(90)90089-x

Abstract

We assessed the association between radial bone mass and vitamin D considering age, estrogen sufficiency and thiazide use in 373 women, aged 20-80 years in a geographically defined area. We measured cortical bone mass of the radius, using photon absorptiometry, and serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D, using preliminary chromatography and protein-binding assay. We found that 1,25-dihydroxyvitamin D levels were higher in premenopausal women and postmenopausal women using estrogen replacement as compared to postmenopausal women (P less than 0.02). Users of thiazide-based antihypertensive medications had significantly lower 1,25-dihydroxyvitamin D than their age-matched peers (P less than 0.02). Dietary calcium intake was negatively associated with 1,25-dihydroxyvitamin D levels. Estimates of vitamin D intake from diet or sunlight were not associated with 1,25-dihydroxyvitamin D levels; nor were levels of 1,25-dihydroxyvitamin D related to 25-hydroxyvitamin D levels. 1,25-Dihydroxyvitamin D was negatively and significantly associated with radial bone mass, contributing approximately 6% of the explained variability of bone mass measurements. Together age, body size, thiazide use and 1,25-dihydroxyvitamin D accounted for about 47% of the explained variability in radial bone mass measurement. 1,25-Dihydroxyvitamin D was not associated with bone mass in women currently using a thiazide medication.

Similar articles

Substances

MeSH terms

Publication Types

Grant support

LinkOut - more resources