Jpn J Pharmacol. 1990 Nov;54(3):339-43. doi: 10.1254/jjp.54.339.

Effects of thiamine administration on hypothermia and hypothalamic histamine levels in dietary-induced thiamine deficient rats.

Japanese journal of pharmacology

K Onodera, H Shinoda, T Watanabe

PMID: 2090843 DOI: 10.1254/jjp.54.339
Free Article

Abstract

The rats maintained on a thiamine-deficient diet for 30 days showed hypothermia, and their histamine levels increased significantly in both the anterior and posterior hypothalamus. When these rats were administered, thiamine disulfide and/or provided with thiamine-added diet for a further 30 days, the rats recovered from hypothermia, and histamine levels were decreased to the normal level. Thus, it is probable that the increased histamine levels in the hypothalamus, especially those in its anterior region, are closely related to the hypothermia in thiamine-deficient rats.

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Substances

• Histamine
• Thiamine

MeSH terms

• Animals
• Body Temperature / drug effects
• Diet
• Histamine / metabolism
• Hypothalamus / drug effects
• Hypothalamus / metabolism
• Male
• Rats
• Rats, Inbred Strains
• Thiamine / pharmacology
• Thiamine Deficiency / metabolism

Publication Types

• Journal Article
• Research Support, Non-U.S. Gov't

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