J Lipid Res. 1990 Dec;31(12):2141-7.

Effects of dietary monounsaturated fatty acids on plasma lipids in humans.

Journal of lipid research

N W Chang, P C Huang

PMID: 2090708
Free Article

Abstract

In order to test whether monounsaturated fatty acids (MUFA, M) would lower plasma cholesterol and/or triglycerides (TG), 14 young men were studied in a metabolism ward. They were given two experimental diets with the same P/S ratio (P: polyunsaturated; S:saturated fatty acids) but different P + M/S ratios in composition of dietary fatty acids. Six men were in experiment I. In two groups of three, each group was given either the high or the low P + M/S ratio diet for 6 weeks. In experiment II, two groups of four men were subjected to a 3-week cross-over feeding trial (total of 6 weeks). We found in the crossover study that when the dietary P/S ratio was fixed at 1.0, those subjects given a diet with the higher P + M/S ratio of 4.5 showed significantly higher plasma total TG, very low density lipoprotein (VLDL)-TG, low density lipoprotein (LDL)-TG, and LDL-cholesterol than when given a diet with a lower P + M/S ratio of 1.5. Plasma total cholesterol, apoprotein A-I, and apoprotein B-100 were not significantly different between the two dietary periods. Plasma fatty acid patterns showed a significantly higher plasma MUFA level during the period of a higher P + M/S diet. In contrast to some recent reports, our studies indicate that a large amount of dietary MUFA may raise some fractions of plasma lipids in humans.

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Substances

• Dietary Fats, Unsaturated
• Fatty Acids, Monounsaturated
• Phospholipids
• Triglycerides
• Cholesterol

MeSH terms

• Adult
• Cholesterol / blood
• Diet
• Dietary Fats, Unsaturated / administration & dosage
• Fatty Acids, Monounsaturated / administration & dosage
• Humans
• Male
• Phospholipids / blood
• Triglycerides / blood

Publication Types

• Journal Article
• Research Support, Non-U.S. Gov't

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