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Hayashida CY, Duarte AJ, Sato AE, et al. Neonatal hepatitis and lymphocyte sensitization by placental transfer of propylthiouracil. J Endocrinol Invest. 1990;13(11):937-41doi: 10.1007/BF03349663.
Hayashida, C. Y., Duarte, A. J., Sato, A. E., & Yamashiro-Kanashiro, E. H. (1990). Neonatal hepatitis and lymphocyte sensitization by placental transfer of propylthiouracil. Journal of endocrinological investigation, 13(11), 937-41. https://doi.org/10.1007/BF03349663
Hayashida, C Y, et al. "Neonatal hepatitis and lymphocyte sensitization by placental transfer of propylthiouracil." Journal of endocrinological investigation vol. 13,11 (1990): 937-41. doi: https://doi.org/10.1007/BF03349663
Hayashida CY, Duarte AJ, Sato AE, Yamashiro-Kanashiro EH. Neonatal hepatitis and lymphocyte sensitization by placental transfer of propylthiouracil. J Endocrinol Invest. 1990 Dec;13(11):937-41. doi: 10.1007/BF03349663. PMID: 2090674.
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J Endocrinol Invest. 1990 Dec;13(11):937-41. doi: 10.1007/BF03349663.

Neonatal hepatitis and lymphocyte sensitization by placental transfer of propylthiouracil.

Journal of endocrinological investigation

C Y Hayashida, A J Duarte, A E Sato, E H Yamashiro-Kanashiro

Affiliations

  1. Department of Medicine, School of Medicine, São Paulo University, Brasil.

PMID: 2090674 DOI: 10.1007/BF03349663

Abstract

A female newborn whose mother was taking propylthiouracil (PTU) for Graves' disease, presented with transient thyrotoxicosis (serum triiodothyronine 1,710 ng/dl) and signs of acute hepatic injury. Jaundice and choluria were evident on her fourth day of life. Serum total bilirubin reached 14 mg/dl, with a direct fraction of 11 mg/dl. Serum alanine aminotransferase and aspartate aminotransferase showed moderate elevations (110 IU/l and 61.5 IU/l, respectively), as well as the alkaline phosphatase which increased to about twice the upper limit of normal. When incubated with PTU, the patient's cultured peripheral lymphocytes underwent transformation to more than twice the values found in 2 controls, with a stimulation index (SI) of 3.19, compared to SI of 1.45 and 1.15 for the controls, suggesting a hypersensitivity mechanism involved in the hepatic injury. Although about 20 cases of PTU induced hepatic damage were reported in the medical literature, this is, as far as we know, the first description of neonatal liver injury probably caused by placental transfer of this drug.

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