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Philpott CC, Leidgens S, Frey AG. Metabolic remodeling in iron-deficient fungi. Biochim Biophys Acta. 2012;1823(9):1509-20doi: 10.1016/j.bbamcr.2012.01.012.
Philpott, C. C., Leidgens, S., & Frey, A. G. (2012). Metabolic remodeling in iron-deficient fungi. Biochimica et biophysica acta, 1823(9), 1509-20. https://doi.org/10.1016/j.bbamcr.2012.01.012
Philpott, Caroline C, et al. "Metabolic remodeling in iron-deficient fungi." Biochimica et biophysica acta vol. 1823,9 (2012): 1509-20. doi: https://doi.org/10.1016/j.bbamcr.2012.01.012
Philpott CC, Leidgens S, Frey AG. Metabolic remodeling in iron-deficient fungi. Biochim Biophys Acta. 2012 Sep;1823(9):1509-20. doi: 10.1016/j.bbamcr.2012.01.012. Epub 2012 Jan 27. PMID: 22306284; PMCID: PMC3348335.
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Biochim Biophys Acta. 2012 Sep;1823(9):1509-20. doi: 10.1016/j.bbamcr.2012.01.012. Epub 2012 Jan 27.

Metabolic remodeling in iron-deficient fungi.

Biochimica et biophysica acta

Caroline C Philpott, Sébastien Leidgens, Avery G Frey

Affiliations

  1. Genetics and Metabolism Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bldg. 10, Rm. 9B-16, 10 Center Drive, Bethesda, MD 20892, USA. [email protected]

PMID: 22306284 PMCID: PMC3348335 DOI: 10.1016/j.bbamcr.2012.01.012

Abstract

Eukaryotic cells contain dozens, perhaps hundreds, of iron-dependent proteins, which perform critical functions in nearly every major cellular process. Nutritional iron is frequently available to cells in only limited amounts; thus, unicellular and higher eukaryotes have evolved mechanisms to cope with iron scarcity. These mechanisms have been studied at the molecular level in the model eukaryotes Saccharomyces cerevisiae and Schizosaccharomyces pombe, as well as in some pathogenic fungi. Each of these fungal species exhibits metabolic adaptations to iron deficiency that serve to reduce the cell's reliance on iron. However, the regulatory mechanisms that accomplish these adaptations differ greatly between fungal species. This article is part of a Special Issue entitled: Cell Biology of Metals.

Published by Elsevier B.V.

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