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Sozzi G, Miozzo M, Calderone C, et al. Chromosome abnormalities and fragile sites in human melanoma. Cancer Genet Cytogenet. 1990;44(1):61-7doi: 10.1016/0165-4608(90)90198-j.
Sozzi, G., Miozzo, M., Calderone, C., Fossati, G., Pierotti, M. A., Cascinelli, N., & Della Porta, G. (1990). Chromosome abnormalities and fragile sites in human melanoma. Cancer genetics and cytogenetics, 44(1), 61-7. https://doi.org/10.1016/0165-4608(90)90198-j
Sozzi, G, et al. "Chromosome abnormalities and fragile sites in human melanoma." Cancer genetics and cytogenetics vol. 44,1 (1990): 61-7. doi: https://doi.org/10.1016/0165-4608(90)90198-j
Sozzi G, Miozzo M, Calderone C, Fossati G, Pierotti MA, Cascinelli N, Della Porta G. Chromosome abnormalities and fragile sites in human melanoma. Cancer Genet Cytogenet. 1990 Jan;44(1):61-7. doi: 10.1016/0165-4608(90)90198-j. PMID: 2293881.
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Cancer Genet Cytogenet. 1990 Jan;44(1):61-7. doi: 10.1016/0165-4608(90)90198-j.

Chromosome abnormalities and fragile sites in human melanoma.

Cancer genetics and cytogenetics

G Sozzi, M Miozzo, C Calderone, G Fossati, M A Pierotti, N Cascinelli, G Della Porta

Affiliations

  1. Division of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.

PMID: 2293881 DOI: 10.1016/0165-4608(90)90198-j

Abstract

Chromosome analysis in short-term lines of three primary and seven metastatic malignant melanomas showed aneuploid karyotypes with recurrent abnormalities of chromosomes 1 (five cell lines), 6 (nine cell lines), and 7 (six cell lines). The breakpoints observed on the rearranged chromosomes frequently coincided with loci of known oncogenes and fragile sites. Two of the cell lines were analyzed after xenograft into nude mice and showed the presence of the same chromosomal changes observed in the parental cell lines, indicating the stability of the karyotype. A tendency toward an increased chromosomal fragility in peripheral blood lymphocytes was observed in five melanoma patients compared to ten normal individuals. However, there was no increased level of expression of specific fragile sites corresponding to the breakpoints observed in melanoma cells.

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