Display options
Cite
Peng RY, Mansbach RS, Braff DL, et al. A D2 dopamine receptor agonist disrupts sensorimotor gating in rats. Implications for dopaminergic abnormalities in schizophrenia. Neuropsychopharmacology. 1990;3(3):211-8
Peng, R. Y., Mansbach, R. S., Braff, D. L., & Geyer, M. A. (1990). A D2 dopamine receptor agonist disrupts sensorimotor gating in rats. Implications for dopaminergic abnormalities in schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 3(3), 211-8.
Peng, R Y, et al. "A D2 dopamine receptor agonist disrupts sensorimotor gating in rats. Implications for dopaminergic abnormalities in schizophrenia." Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology vol. 3,3 (1990): 211-8.
Peng RY, Mansbach RS, Braff DL, Geyer MA. A D2 dopamine receptor agonist disrupts sensorimotor gating in rats. Implications for dopaminergic abnormalities in schizophrenia. Neuropsychopharmacology. 1990 Jun;3(3):211-8. PMID: 2141986.
Copy Download .nbib Format: NLM
Share it on

Neuropsychopharmacology. 1990 Jun;3(3):211-8.

A D2 dopamine receptor agonist disrupts sensorimotor gating in rats. Implications for dopaminergic abnormalities in schizophrenia.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

R Y Peng, R S Mansbach, D L Braff, M A Geyer

Affiliations

  1. Department of Psychiatry, University of California, San Diego, La Jolla 92093.

PMID: 2141986

Abstract

Prepulse inhibition of acoustic startle is deficient in schizophrenic patients and in animals injected with either direct or indirect dopamine (DA) agonists. The present experiments confirmed the hypothesis that the dopaminergic blockade of prepulse inhibition is attributable to the activation of D2 DA receptors. After systemic administrations of the D1 agonist SK&F 38393, the D2 agonist quinpirole, or a combination of the two, rats were tested for prepulse inhibition of the startle response by presenting acoustic stimuli or acoustic stimuli preceded by weak prepulses that inhibit startle. Although the D1 agonist SK&F 38393 had no effect on prepulse inhibition [0.3 to 30.0 mg/kg (1.03 to 102.82 mumols/kg)], the D agonist, quinpirole, blocked prepulse inhibition at doses of 0.3 mg/kg (1.17 mumols/kg) and 0.9 mg/kg (3.51 mumols/kg). Lower doses of quinpirole, 0.03 mg/kg (0.12 mumols/kg) and 0.1 mg/kg (0.39 mumols/kg), were ineffective. When an ineffective dose of quinpirole (0.1 mg/kg) was coadministered with 10.0 mg/kg SKF 38393, prepulse inhibition was reduced relative to saline controls. This reduction of prepulse inhibition is consistent with the synergistic effect of D1 and D2 DA receptor stimulation noted in studies of dopaminergic influences on stereotyped behavior in rats. These findings confirm that a disruption of sensorimotor gating results from D2 dopaminergic stimulation in the rat and extend the applicability of this animal model for the similar behavioral deficits exhibited by schizophrenic patients.

Similar articles

Show all 12 similar articles

Cited by

Substances

MeSH terms

Publication Types

Grant support

LinkOut - more resources