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Lee SJ, Cho SA, An SS, et al. Alstonia scholaris R. Br. Significantly Inhibits Retinoid-Induced Skin Irritation In Vitro and In Vivo. Evid Based Complement Alternat Med. 2011;2012:190370doi: 10.1155/2012/190370.
Lee, S. J., Cho, S. A., An, S. S., Na, Y. J., Park, N. H., Kim, H. S., Lee, C. W., Kim, H. K., Kim, E. K., Jang, Y. P., & Kim, J. W. (2012). Alstonia scholaris R. Br. Significantly Inhibits Retinoid-Induced Skin Irritation In Vitro and In Vivo. Evidence-based complementary and alternative medicine : eCAM, 2012190370. https://doi.org/10.1155/2012/190370
Lee, Soo-Jin, et al. "Alstonia scholaris R. Br. Significantly Inhibits Retinoid-Induced Skin Irritation In Vitro and In Vivo." Evidence-based complementary and alternative medicine : eCAM vol. 2012 (2012): 190370. doi: https://doi.org/10.1155/2012/190370
Lee SJ, Cho SA, An SS, Na YJ, Park NH, Kim HS, Lee CW, Kim HK, Kim EK, Jang YP, Kim JW. Alstonia scholaris R. Br. Significantly Inhibits Retinoid-Induced Skin Irritation In Vitro and In Vivo. Evid Based Complement Alternat Med. 2012;2012:190370. doi: 10.1155/2012/190370. Epub 2011 Sep 08. PMID: 21912567; PMCID: PMC3170789.
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Evid Based Complement Alternat Med. 2012;2012:190370. doi: 10.1155/2012/190370. Epub 2011 Sep 08.

Alstonia scholaris R. Br. Significantly Inhibits Retinoid-Induced Skin Irritation In Vitro and In Vivo.

Evidence-based complementary and alternative medicine : eCAM

Soo-Jin Lee, Sun-A Cho, Su-Sun An, Yong-Joo Na, Nok-Hyun Park, Han-Sung Kim, Chan-Woo Lee, Han-Kon Kim, Eun-Kyung Kim, Young-Pyo Jang, Jin-Woong Kim

Affiliations

  1. Amorepacific Co. R&D Center, Bora-dong, Giheung-gu, Yongin-si, Gyeonggi-do 449-729, Republic of Korea.

PMID: 21912567 PMCID: PMC3170789 DOI: 10.1155/2012/190370

Abstract

Topical retinoids inhibit matrix metalloproteinases and accelerate collagen synthesis, thereby triggering antiaging effects in the skin. However, topical retinoids can cause severe skin reactions, including scaling, erythema, papules, and inflammation. The present study demonstrates that the ethanolic bark extract of Alstonia scholaris R. Br. can significantly inhibit all-trans retinoic acid-induced inflammation in human HaCat keratinocyte cells. Furthermore, two representative retinoid-induced proinflammatory cytokines, monocyte chemoattractant protein-1 and interleukin-8, were significantly suppressed by A. scholaris extract (by 82.1% and 26.3% at 100 ppm, and dose-dependently across the tested concentrations) in vitro. In a cumulative irritation patch test, A. scholaris extract decreased retinol-induced skin irritation, while strengthening the ability of retinoids to inhibit matrix metalloproteinase-1 expression, which is strongly associated with aging effects. These results suggest that A. scholaris is a promising compound that may increase the antiaging function of retinoids while reducing their ability to cause skin irritation.

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