Display options
Cite
Coller BS. Historical perspective and future directions in platelet research. J Thromb Haemost. 2011;9:374-95doi: 10.1111/j.1538-7836.2011.04356.x.
Coller, B. S. (2011). Historical perspective and future directions in platelet research. Journal of thrombosis and haemostasis : JTH, 9374-95. https://doi.org/10.1111/j.1538-7836.2011.04356.x
Coller, B S. "Historical perspective and future directions in platelet research." Journal of thrombosis and haemostasis : JTH vol. 9 (2011): 374-95. doi: https://doi.org/10.1111/j.1538-7836.2011.04356.x
Coller BS. Historical perspective and future directions in platelet research. J Thromb Haemost. 2011 Jul;9:374-95. doi: 10.1111/j.1538-7836.2011.04356.x. PMID: 21781274; PMCID: PMC3163479.
Copy Download .nbib Format: NLM
Share it on

J Thromb Haemost. 2011 Jul;9:374-95. doi: 10.1111/j.1538-7836.2011.04356.x.

Historical perspective and future directions in platelet research.

Journal of thrombosis and haemostasis : JTH

B S Coller

Affiliations

  1. Laboratory of Blood and Vascular Biology, Rockefeller University, New York, NY, USA.

PMID: 21781274 PMCID: PMC3163479 DOI: 10.1111/j.1538-7836.2011.04356.x

Abstract

Platelets are a remarkable mammalian adaptation that are required for human survival by virtue of their ability to prevent and arrest bleeding. Ironically, however, in the past century, the platelets' hemostatic activity became maladaptive for the increasingly large percentage of individuals who develop age-dependent progressive atherosclerosis. As a result, platelets also make a major contribution to ischemic thrombotic vascular disease, the leading cause of death worldwide. In this brief review, I provide historical descriptions of a highly selected group of topics to provide a framework for understanding our current knowledge and the trends that are likely to continue into the future of platelet research. For convenience, I separate the eras of platelet research into the "Descriptive Period" extending from ~1880-1960 and the "Mechanistic Period" encompassing the past ~50 years since 1960. We currently are reaching yet another inflection point, as there is a major shift from a focus on traditional biochemistry and cell and molecular biology to an era of single molecule biophysics, single cell biology, single cell molecular biology, structural biology, computational simulations, and the high-throughput, data-dense techniques collectively named with the "omics postfix". Given the progress made in understanding, diagnosing, and treating many rare and common platelet disorders during the past 50 years, I think it appropriate to consider it a Golden Age of Platelet Research and to recognize all of the investigators who have made important contributions to this remarkable achievement..

© 2011 International Society on Thrombosis and Haemostasis.

References

  1. Curr Opin Investig Drugs. 2009 Sep;10(9):988-96 - PubMed
  2. Semin Thromb Hemost. 2006 Jul;32(5):445-55 - PubMed
  3. J Biol Chem. 1990 Apr 15;265(11):6346-52 - PubMed
  4. Ann Intern Med. 1953 Mar;38(3):433-69 - PubMed
  5. Br J Haematol. 1970 Nov;19(5):643-9 - PubMed
  6. Thromb Haemost. 2001 Jul;86(1):178-88 - PubMed
  7. J Biol Chem. 1983 Sep 25;258(18):11236-42 - PubMed
  8. Lancet. 2011 Jan 29;377(9763):393-402 - PubMed
  9. J Biol Chem. 1972 May 10;247(9):2723-31 - PubMed
  10. Am J Cardiol. 2009 Jan 1;103(1):5-10 - PubMed
  11. Blood. 2008 Sep 15;112(6):2591 - PubMed
  12. Semin Hematol. 1986 Apr;23(2):89-101 - PubMed
  13. J Thromb Haemost. 2005 May;3(5):834-9 - PubMed
  14. J Clin Invest. 1997 Mar 15;99(6):1351-60 - PubMed
  15. J Cell Biol. 1985 Sep;101(3):880-6 - PubMed
  16. J Exp Med. 1968 Nov 1;128(5):877-94 - PubMed
  17. J Mol Biol. 2009 Dec 18;394(5):944-56 - PubMed
  18. Am J Hematol. 1979;6(1):71-5 - PubMed
  19. J Biol Chem. 1999 Oct 8;274(41):29019-24 - PubMed
  20. Blood. 2001 Jan 1;97(1):139-46 - PubMed
  21. JACC Cardiovasc Interv. 2010 Dec;3(12):1209-19 - PubMed
  22. Int J Hematol. 2002 Nov;76(4):319-27 - PubMed
  23. Semin Oncol. 1990 Apr;17(2):198-209 - PubMed
  24. Semin Thromb Hemost. 2009 Mar;35(2):233-41 - PubMed
  25. Br J Haematol. 1998 Jul;102(2):582-7 - PubMed
  26. Curr Opin Hematol. 1994 Sep;1(5):381-7 - PubMed
  27. Br J Haematol. 1961 Jan;7:42-50 - PubMed
  28. J Clin Invest. 1977 Oct;60(4):866-73 - PubMed
  29. Arterioscler Thromb Vasc Biol. 2000 Mar;20(3):607-10 - PubMed
  30. Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22481-6 - PubMed
  31. Thromb Haemost. 2008 Feb;99(2):253-63 - PubMed
  32. J Thromb Haemost. 2006 Oct;4(10):2103-14 - PubMed
  33. Blood. 1981 Mar;57(3):545-52 - PubMed
  34. Curr Opin Hematol. 2009 Sep;16(5):323-8 - PubMed
  35. Nature. 1976 Jun 17;261(5561):558-60 - PubMed
  36. Blood. 2002 Jan 1;99(1):137-44 - PubMed
  37. Circulation. 2011 Feb 22;123(7):768-78 - PubMed
  38. Curr Pharm Des. 2007;13(26):2673-83 - PubMed
  39. Expert Rev Cardiovasc Ther. 2010 Aug;8(8):1069-77 - PubMed
  40. J Thromb Haemost. 2008 Mar;6(3):415-20 - PubMed
  41. Cancer Sci. 2008 Jan;99(1):54-61 - PubMed
  42. Heart. 2010 Nov;96(22):1815-20 - PubMed
  43. J Biol Chem. 1993 Jan 15;268(2):1066-73 - PubMed
  44. Ann Intern Med. 2000 Mar 7;132(5):364-8 - PubMed
  45. Blood. 2007 Feb 15;109(4):1503-6 - PubMed
  46. J Hepatol. 2011 Jul;55(1):229-32 - PubMed
  47. Semin Hematol. 2004 Jan;41(1):68-74 - PubMed
  48. Prog Hemost Thromb. 1989;9:233-59 - PubMed
  49. Circulation. 1987 Jul;76(1):125-34 - PubMed
  50. Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):11104-8 - PubMed
  51. Lancet. 2011 Jan 29;377(9763):383-92 - PubMed
  52. Cell. 1991 Mar 22;64(6):1057-68 - PubMed
  53. J Thromb Haemost. 2006 Feb;4(2):436-42 - PubMed
  54. Expert Opin Investig Drugs. 2011 Jan;20(1):119-33 - PubMed
  55. J Clin Invest. 2009 Jun;119(6):1489-501 - PubMed
  56. Hum Immunol. 2006 Jun;67(6):413-8 - PubMed
  57. J Clin Invest. 1986 Aug;78(2):340-8 - PubMed
  58. Nat Rev Cancer. 2011 Feb;11(2):123-34 - PubMed
  59. N Engl J Med. 1966 Aug 4;275(5):243-8 - PubMed
  60. J Thromb Haemost. 2005 Aug;3(8):1800-14 - PubMed
  61. Thromb Haemost. 2008 Feb;99(2):264-70 - PubMed
  62. Lancet. 1988 Aug 13;2(8607):349-60 - PubMed
  63. Thromb Haemost. 1995 Jul;74(1):117-22 - PubMed
  64. Nature. 1976 Oct 21;263(5579):663-5 - PubMed
  65. EMBO J. 2009 May 6;28(9):1351-61 - PubMed
  66. J Clin Invest. 1968 Sep;47(9):2169-80 - PubMed
  67. Best Pract Res Clin Haematol. 2010 Jun;23(2):245-57 - PubMed
  68. Blood. 2001 Dec 1;98(12):3241-8 - PubMed
  69. J Biol Chem. 1980 Nov 10;255(21):10227-31 - PubMed
  70. Bone Marrow Transplant. 2000 Jul;26(2):141-5 - PubMed
  71. J Thromb Haemost. 2008 Dec;6(12):2035-44 - PubMed
  72. Am J Clin Pathol. 1969 Jul;52(1):69-77 - PubMed
  73. Am J Med. 1979 Aug;67(2):206-13 - PubMed
  74. Blood. 2008 Oct 15;112(8):3164-74 - PubMed
  75. Blood Rev. 2000 Sep;14(3):145-56 - PubMed
  76. Immunohematology. 2007;23(1):9-13 - PubMed
  77. Arterioscler Thromb Vasc Biol. 2008 Mar;28(3):s25-32 - PubMed
  78. J Thromb Haemost. 2010 Jul;8(7):1584-93 - PubMed
  79. Transfus Med Rev. 1993 Jan;7(1):1-10 - PubMed
  80. J Thromb Haemost. 2005 Jan;3(1):1-6 - PubMed
  81. Thromb Diath Haemorrh. 1957 Aug 15;1(2):257-60 - PubMed
  82. J Thromb Haemost. 2006 Mar;4(3):678-9 - PubMed
  83. Haematologica. 2001 Apr;86(4):349-56 - PubMed
  84. N Engl J Med. 1998 Nov 26;339(22):1585-94 - PubMed
  85. Arterioscler Thromb Vasc Biol. 2011 May;31(5):986-1000 - PubMed
  86. N Engl J Med. 2007 Nov 29;357(22):2227-36 - PubMed
  87. Am J Physiol. 1955 May;181(2):304-8 - PubMed
  88. Curr Pharm Des. 2004;10(14):1587-96 - PubMed
  89. J Biol Chem. 2005 Oct 21;280(42):35490-8 - PubMed
  90. Blood. 2008 Feb 1;111(3):981-6 - PubMed
  91. N Engl J Med. 1982 Dec 2;307(23):1432-5 - PubMed
  92. Thromb Res. 2011 Feb;127 Suppl 3:S61-3 - PubMed
  93. Thromb Haemost. 1997 Sep;78(3):1125-31 - PubMed
  94. Thromb Res. 2007;120(3):337-46 - PubMed
  95. Curr Opin Investig Drugs. 2010 Mar;11(3):340-8 - PubMed
  96. Ann N Y Acad Sci. 1981;370:191-204 - PubMed
  97. Nat Struct Biol. 1995 Aug;2(8):637-43 - PubMed
  98. J Cell Biol. 2008 May 5;181(3):439-46 - PubMed
  99. Mol Cell. 2009 Apr 24;34(2):234-49 - PubMed
  100. J Clin Invest. 1976 Jan;57(1):112-24 - PubMed
  101. Proc Natl Acad Sci U S A. 1983 May;80(9):2417-21 - PubMed
  102. Semin Thromb Hemost. 2008 Oct;34(7):663-9 - PubMed
  103. N Engl J Med. 1984 Oct 25;311(17):1084-98 - PubMed
  104. Blood. 2008 Jun 1;111(11):5271-81 - PubMed
  105. Am J Hematol. 2008 Apr;83(4):304-6 - PubMed
  106. J Biochem. 1980 Sep;88(3):913-6 - PubMed
  107. Thromb Haemost. 1993 Jul 1;70(1):105-10 - PubMed
  108. Adv Prostaglandin Thromboxane Leukot Res. 1985;15:109-12 - PubMed
  109. J Clin Invest. 2005 Feb;115(2):237-46 - PubMed
  110. Circulation. 2003 Jun 17;107(23):2908-13 - PubMed
  111. Br J Haematol. 2010 Mar;148(6):834-43 - PubMed
  112. Lancet. 1997 Aug 9;350(9075):437-9 - PubMed
  113. Blood. 1966 Oct;28(4):524-34 - PubMed
  114. Proc Soc Exp Biol Med. 1954 Feb;85(2):282-5 - PubMed
  115. Drug Saf. 1998 Aug;19(2):89-98 - PubMed
  116. Acta Med Scand. 1963 Feb;173:235-42 - PubMed
  117. Circulation. 2009 Dec 22;120(25):2586-96 - PubMed
  118. Biosci Rep. 1983 Sep;3(9):791-813 - PubMed
  119. J Thromb Haemost. 2009 Nov;7(11):1759-66 - PubMed
  120. Proc Soc Exp Biol Med. 1968 Feb;127(2):547-51 - PubMed
  121. Nat Med. 2009 Mar;15(3):306-12 - PubMed
  122. Med Clin North Am. 1960 Sep;44:1425-39 - PubMed
  123. Transfus Med Rev. 1987 Dec;1(3):195-200 - PubMed
  124. Thromb Diath Haemorrh. 1971 Oct 31;26(2):362-9 - PubMed
  125. Biochem J. 1998 Dec 15;336 ( Pt 3):513-23 - PubMed
  126. Blood. 1960 Jul;16:943-57 - PubMed
  127. J Thromb Haemost. 2009 Jul;7 Suppl 1:253-7 - PubMed
  128. Haemophilia. 2006 Nov;12(6):563-72 - PubMed
  129. J Lab Clin Med. 1951 Jul;38(1):1-10 - PubMed
  130. J Exp Med. 2010 Dec 20;207(13):2781-4 - PubMed
  131. Blood. 1972 Feb;39(2):197-209 - PubMed
  132. Blood. 1987 May;69(5):1401-3 - PubMed
  133. Platelets. 2008 Feb;19(1):9-23 - PubMed
  134. Arterioscler Thromb Vasc Biol. 1999 Dec;19(12):2841-6 - PubMed
  135. Acta Med Scand. 1957 Nov 29;159(3):179-88 - PubMed
  136. Transfus Med Rev. 2008 Oct;22(4):255-67 - PubMed
  137. Blood. 2008 Feb 1;111(3):1227-33 - PubMed
  138. Thromb Haemost. 1997 Jul;78(1):581-9 - PubMed
  139. Science. 2002 Aug 16;297(5584):1176-9 - PubMed
  140. J Clin Pathol. 1962 Sep;15(5):452-5 - PubMed
  141. Blood. 2010 Dec 2;116(23):5050-9 - PubMed
  142. Blood. 2007 Jun 1;109(11):4607-16 - PubMed
  143. Nature. 1962 Jun 9;194:927-9 - PubMed
  144. Blood. 2005 Dec 15;106(13):4066-75 - PubMed
  145. Prog Hematol. 1979;11:147-71 - PubMed
  146. Blood Cells. 1989;15(1):23-47 - PubMed
  147. Mini Rev Med Chem. 2007 Dec;7(12):1248-54 - PubMed
  148. J Clin Invest. 1983 Jul;72(1):325-38 - PubMed
  149. J Thromb Haemost. 2005 Aug;3(8):1752-62 - PubMed
  150. Lancet. 1996 Nov 16;348(9038):1329-39 - PubMed
  151. J Thromb Haemost. 2005 Aug;3(8):1745-51 - PubMed
  152. Blood. 2006 Jan 15;107(2):542-9 - PubMed
  153. Blood. 2008 Oct 1;112(7):2607-16 - PubMed
  154. Ser Haematol. 1971;4(1):3-27 - PubMed
  155. Experientia. 1988 Feb 15;44(2):97-100 - PubMed
  156. Blood. 1988 Apr;71(4):831-43 - PubMed
  157. Ann N Y Acad Sci. 2011 Mar;1222:55-63 - PubMed
  158. N Engl J Med. 2009 Jan 22;360(4):354-62 - PubMed
  159. Transfusion. 2010 Dec;50(12):2753-60 - PubMed
  160. Blood. 1948 Oct;3(10):1073-82 - PubMed
  161. FEBS Lett. 1994 Oct 10;353(1):57-61 - PubMed
  162. J Med Chem. 1992 Nov 27;35(24):4640-2 - PubMed
  163. J Thromb Haemost. 2005 Sep;3(9):1905-9 - PubMed
  164. Nat Med. 2011 Jan;17(1):110-6 - PubMed
  165. J Thromb Haemost. 2011 Jun;9(6):1097-107 - PubMed
  166. Thromb Haemost. 2011 Mar;105(3):545-52 - PubMed
  167. Semin Thromb Hemost. 2005 Apr;31(2):234-46 - PubMed
  168. Semin Thromb Hemost. 2006 Mar;32(2):81-9 - PubMed
  169. Future Cardiol. 2010 Jul;6(4):445-53 - PubMed
  170. Ann N Y Acad Sci. 1991;614:125-37 - PubMed
  171. Thromb Haemost. 1999 Aug;82(2):585-91 - PubMed
  172. J Thromb Haemost. 2009 Jul;7 Suppl 1:210-3 - PubMed
  173. Am Heart J. 2011 Mar;161(3):478-486.e7 - PubMed
  174. Br Med J (Clin Res Ed). 1988 Jan 30;296(6618):320-31 - PubMed
  175. J Biol Chem. 2010 Aug 6;285(32):24494-507 - PubMed
  176. Thromb Haemost. 1978 Oct 31;40(2):232-40 - PubMed
  177. Blood. 2008 Oct 15;112(8):3011-25 - PubMed
  178. N Engl J Med. 1996 Apr 25;334(17):1084-9 - PubMed
  179. Circulation. 1995 Nov 1;92(9):2373-80 - PubMed
  180. Vox Sang. 2002 Aug;83 Suppl 1:287-8 - PubMed
  181. Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1614-9 - PubMed
  182. Nat Med. 2010 Feb;16(2):232-6 - PubMed
  183. Cell Res. 2011 Mar;21(3):530-45 - PubMed
  184. Hematology Am Soc Hematol Educ Program. 2009;:153-8 - PubMed
  185. Semin Hematol. 1985 Oct;22(4):241-59 - PubMed
  186. J Invasive Cardiol. 2010 Jun;22(6):278-82 - PubMed
  187. Am J Surg Pathol. 2002 Jan;26(1):88-96 - PubMed
  188. Lancet. 1996 Nov 9;348(9037):1279-81 - PubMed
  189. Curr Drug Targets. 2006 Oct;7(10):1253-63 - PubMed
  190. Nature. 1994 Jun 16;369(6481):533-8 - PubMed
  191. Thromb Haemost. 1996 Jun;75(6):865-9 - PubMed
  192. Blood Cells. 1983;9(2):179-93 - PubMed
  193. Blood. 2009 May 7;113(19):4740-6 - PubMed
  194. J Cell Biol. 1999 Dec 13;147(6):1299-312 - PubMed
  195. Blood. 1989 Jul;74(1):182-92 - PubMed
  196. J Exp Med. 2010 Dec 20;207(13):2817-30 - PubMed
  197. Blood. 2011 Apr 7;117(14):3893-902 - PubMed
  198. Blood. 2007 Apr 15;109(8):3284-90 - PubMed
  199. Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17729-34 - PubMed
  200. Hematol Oncol Clin North Am. 1990 Feb;4(1):291-311 - PubMed
  201. J Clin Invest. 1991 Apr;87(4):1234-40 - PubMed
  202. Exp Hematol. 1989 Sep;17(8):903-7 - PubMed
  203. Nat Med. 2009 Mar;15(3):313-8 - PubMed
  204. Ultrastruct Pathol. 1980 Oct-Dec;1(4):533-58 - PubMed
  205. Blood. 1987 Jul;70(1):110-5 - PubMed
  206. J Clin Invest. 1988 Aug;82(2):739-43 - PubMed
  207. J Clin Invest. 1980 Dec;66(6):1311-8 - PubMed
  208. Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2357-61 - PubMed
  209. Acta Haematol. 1958 Dec;20(6):350-5 - PubMed
  210. Blood. 1993 Mar 15;81(6):1411-3 - PubMed
  211. J Clin Invest. 1997 Apr 1;99(7):1467-71 - PubMed
  212. Circulation. 2004 Jun 29;109(25):3171-5 - PubMed
  213. J Biol Chem. 2004 May 28;279(22):23327-34 - PubMed
  214. Structure. 2008 Jan;16(1):72-81 - PubMed
  215. Proc Natl Acad Sci U S A. 1974 Feb;71(2):345-9 - PubMed
  216. J Clin Invest. 1999 Jan;103(1):5-9 - PubMed
  217. J Biol Chem. 1985 Sep 15;260(20):11107-14 - PubMed
  218. Lancet. 1985 Dec 21-28;2(8469-70):1419 - PubMed
  219. Lancet. 1987 Nov 7;2(8567):1057-8 - PubMed
  220. Am J Hematol. 2009 Jun;84(6):366-70 - PubMed
  221. Ser Haematol. 1971;4(1):59-74 - PubMed
  222. Expert Opin Pharmacother. 2010 Sep;11(13):2251-9 - PubMed
  223. J Thromb Haemost. 2009 Oct;7(10):1718-26 - PubMed
  224. J Biochem. 1982 Jan;91(1):403-6 - PubMed
  225. Clin Pharmacol Ther. 1994 Oct;56(4):377-88 - PubMed
  226. J Biol Chem. 1989 Oct 15;264(29):17049-57 - PubMed
  227. Thromb Haemost. 1991 Jul 12;66(1):111-8 - PubMed
  228. Proc Natl Acad Sci U S A. 1968 Sep;61(1):46-52 - PubMed
  229. Am J Cardiovasc Drugs. 2001;1(6):421-8 - PubMed
  230. Thromb Haemost. 2007 Jul;98(1):55-62 - PubMed
  231. Circulation. 2011 Feb 1;123(4):451-6 - PubMed
  232. Blood. 1987 Jul;70(1):307-15 - PubMed
  233. Am J Cardiovasc Drugs. 2010;10(6):413-8 - PubMed
  234. J Cell Biol. 2010 Jan 11;188(1):157-73 - PubMed
  235. Eur Heart J. 2009 Nov;30(22):2705-13 - PubMed
  236. Am J Physiol. 1991 Feb;260(2 Pt 1):C242-8 - PubMed
  237. Blood. 2010 Jul 29;116(4):661-70 - PubMed
  238. Nature. 2004 Nov 4;432(7013):59-67 - PubMed
  239. Ann N Y Acad Sci. 1991;614:193-213 - PubMed
  240. Blood. 2003 Jul 15;102(2):449-61 - PubMed
  241. Vox Sang. 1994;67 Suppl 3:271-3 - PubMed
  242. Blood. 1997 May 1;89(9):3097-103 - PubMed
  243. Blood. 2001 Sep 1;98(5):1456-63 - PubMed
  244. Thromb Haemost. 1977 Dec 15;38(4):924-38 - PubMed
  245. Ann N Y Acad Sci. 1991;614:270-8 - PubMed
  246. Nat New Biol. 1972 Mar 29;236(65):104-6 - PubMed
  247. Blood Rev. 2010 May;24(3):123-34 - PubMed
  248. Semin Thromb Hemost. 2010 Nov;36(8):881-7 - PubMed
  249. Platelets. 1990;1(1):3-9 - PubMed
  250. Acta Med Scand. 1959 Jun 30;164:263-78 - PubMed
  251. Curr Opin Hematol. 1999 Nov;6(6):437-41 - PubMed
  252. Science. 1976 Apr 2;192(4234):56-9 - PubMed
  253. Semin Hematol. 2010 Jul;47(3):243-8 - PubMed
  254. JACC Cardiovasc Interv. 2008 Dec;1(6):649-53 - PubMed
  255. Blood. 2001 Sep 15;98(6):1662-6 - PubMed
  256. Blood. 1985 Aug;66(2):423-7 - PubMed
  257. Science. 2006 Apr 7;312(5770):104-7 - PubMed
  258. J Virol. 2006 Sep;80(18):8951-60 - PubMed
  259. Cochrane Database Syst Rev. 2010 Sep 08;(9):CD002130 - PubMed
  260. Arterioscler Thromb Vasc Biol. 1999 Oct;19(10):2281-5 - PubMed
  261. Science. 2010 Jan 15;327(5963):340-3 - PubMed
  262. Blood. 1990 Jan 1;75(1):128-38 - PubMed
  263. Nature. 2001 Oct 4;413(6855):488-94 - PubMed
  264. Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):855-60 - PubMed
  265. Methods Mol Biol. 1999;96:159-70 - PubMed
  266. Blood. 2009 Mar 19;113(12):2619-28 - PubMed
  267. Lancet. 1967 Sep 2;2(7514):495-7 - PubMed
  268. Hematology Am Soc Hematol Educ Program. 2009;:106-12 - PubMed
  269. Circ Res. 2001 Apr 27;88(8):756-62 - PubMed
  270. Nat Clin Pract Cardiovasc Med. 2008 Dec;5(12):766-80 - PubMed
  271. Baillieres Clin Haematol. 1989 Jul;2(3):569-83 - PubMed
  272. J Thromb Haemost. 2009 Dec;7(12):2074-84 - PubMed
  273. Biochemistry. 2005 Dec 27;44(51):16920-30 - PubMed
  274. J Am Med Assoc. 1958 Apr 12;166(15):1805-15 - PubMed
  275. J Thromb Haemost. 2007 Apr;5(4):661-9 - PubMed
  276. Semin Thromb Hemost. 2009 Mar;35(2):189-203 - PubMed
  277. Cell Mol Life Sci. 2010 Feb;67(4):499-511 - PubMed
  278. J Thromb Haemost. 2005 Jun;3(6):1125-32 - PubMed
  279. Genes Dev. 2010 Aug 1;24(15):1659-72 - PubMed
  280. J Biol Chem. 1993 Oct 5;268(28):21080-7 - PubMed
  281. Blood. 1973 May;41(5):687-90 - PubMed
  282. Blood Coagul Fibrinolysis. 1993 Feb;4(1):139-42 - PubMed
  283. Nat New Biol. 1971 Jun 23;231(25):235-7 - PubMed
  284. Thromb Haemost. 1995 Jul;74(1):213-7 - PubMed
  285. Scand J Immunol. 2009 Dec;70(6):531-4 - PubMed
  286. Am J Ther. 2007 Jan-Feb;14(1):106-12 - PubMed
  287. JAMA. 2010 Oct 27;304(16):1821-30 - PubMed
  288. Biochemistry. 2011 Mar 29;50(12):2264-73 - PubMed
  289. Br J Pharmacol. 1987 Nov;92(3):639-46 - PubMed
  290. Thromb Haemost. 2011 May;105(5):752-9 - PubMed
  291. J Clin Invest. 1959 Oct;38:1689-97 - PubMed
  292. J Thromb Haemost. 2005 May;3(5):1116 - PubMed
  293. Baillieres Best Pract Res Clin Haematol. 2000 Dec;13(4):549-63 - PubMed
  294. Transfus Med Rev. 1999 Jul;13(3):153-63 - PubMed
  295. J Biol Chem. 1990 Jul 25;265(21):12267-71 - PubMed
  296. Circ Res. 2004 Oct 15;95(8):814-21 - PubMed
  297. J Clin Invest. 1971 Jan;50(1):244-54 - PubMed
  298. J Clin Invest. 1961 Sep;40(9):1597-620 - PubMed
  299. Prog Hemost Thromb. 1989;9:117-56 - PubMed
  300. Thromb Res. 2004;114(4):221-33 - PubMed
  301. Blood. 2009 Aug 6;114(6):1243-9 - PubMed
  302. Br J Haematol. 2002 Dec;119(4):998-1004 - PubMed
  303. Circulation. 1976 Sep;54(3):365-70 - PubMed
  304. Lancet. 1968 Jun 29;1(7557):1431 - PubMed
  305. PLoS One. 2011 Jan 14;6(1):e14513 - PubMed
  306. Cancer Treat Res. 2011;157:267-88 - PubMed
  307. Semin Hematol. 2010 Jul;47(3):289-98 - PubMed
  308. Annu Rev Med. 1978;29:41-9 - PubMed
  309. Am J Cardiol. 1997 Aug 18;80(4A):11B-20B - PubMed
  310. Blood. 2008 Jun 1;111(11):5298-306 - PubMed
  311. Nat Rev Cardiol. 2010 Sep;7(9):498-509 - PubMed
  312. J Clin Invest. 2005 Dec;115(12):3348-54 - PubMed
  313. Semin Thromb Hemost. 2004 Aug;30(4):461-71 - PubMed
  314. Biochim Biophys Acta. 2008 May;1783(5):673-94 - PubMed
  315. Rev Hematol. 1953;8(3):361-70 - PubMed
  316. Nat New Biol. 1971 Jun 23;231(25):237-9 - PubMed
  317. Nat New Biol. 1971 Jun 23;231(25):232-5 - PubMed
  318. Platelets. 2001 Aug;12(5):261-73 - PubMed
  319. Lancet. 2009 May 30;373(9678):1849-60 - PubMed
  320. J Clin Invest. 1989 Nov;84(5):1440-5 - PubMed
  321. Vasc Health Risk Manag. 2010 Oct 21;6:963-77 - PubMed
  322. Blood. 2005 Dec 15;106(13):4076-85 - PubMed
  323. Semin Hematol. 1994 Oct;31(4):312-9 - PubMed
  324. Exp Hematol. 1981 Mar;9(3):288-96 - PubMed
  325. Nat Med. 2010 Jan;16(1):75-82 - PubMed
  326. J Thromb Haemost. 2007 Jul;5(7):1353-60 - PubMed
  327. Microcirculation. 2009 Jan;16(1):58-83 - PubMed
  328. Cell. 1994 Jul 1;77(7):1117-24 - PubMed
  329. Int J Biochem Cell Biol. 1997 Jan;29(1):91-105 - PubMed
  330. J Thromb Haemost. 2003 Sep;1(9):1869-75 - PubMed
  331. Nature. 1961 Nov 11;192:531-2 - PubMed
  332. Eur Heart J. 2010 Nov;31(21):2601-13 - PubMed
  333. Transfus Med Rev. 1999 Oct;13(4):323-33 - PubMed
  334. Blood. 1999 Dec 1;94(11):3694-701 - PubMed
  335. Curr Opin Hematol. 2010 Sep;17(5):405-10 - PubMed
  336. Hum Mutat. 2010 Jan;31(1):11-9 - PubMed
  337. Am J Roentgenol Radium Ther Nucl Med. 1952 May;67(5):796-804 - PubMed
  338. Ann Intern Med. 2009 Mar 17;150(6):396-404 - PubMed
  339. Nature. 1984 May 3-9;309(5963):30-3 - PubMed
  340. Ann N Y Acad Sci. 1987;516:398-406 - PubMed
  341. Blood. 1993 May 1;81(9):2348-56 - PubMed
  342. Thromb Haemost. 2010 Nov;104(5):894-902 - PubMed
  343. N Engl J Med. 1978 Jun 15;298(24):1350-2 - PubMed
  344. J Thromb Haemost. 2006 Jan;4(1):3-9 - PubMed
  345. Nature. 1962 Feb 24;193:777-8 - PubMed
  346. Blood. 2002 Oct 15;100(8):2793-800 - PubMed
  347. Blood. 1997 Dec 15;90(12):4789-98 - PubMed
  348. Thromb Res. 1981 Aug 15-Sep 1;23(4-5):457-63 - PubMed
  349. Science. 2007 Sep 21;317(5845):1767-70 - PubMed
  350. Methods Enzymol. 2003;365:39-59 - PubMed
  351. Biophys J. 2009 Oct 21;97(8):2232-41 - PubMed
  352. Blood. 1995 May 15;85(10):2720-30 - PubMed
  353. Blood. 1983 Jan;61(1):99-110 - PubMed
  354. Thromb Haemost. 1993 Jul 1;70(1):80-6 - PubMed
  355. J Clin Invest. 1986 Jul;78(1):130-7 - PubMed
  356. Int J Cardiol. 2008 Aug 18;128(2):166-71 - PubMed
  357. Br J Haematol. 1967 Jul;13(4):618-37 - PubMed
  358. Proc Natl Acad Sci U S A. 1977 Sep;74(9):3922-6 - PubMed
  359. Blood. 1999 Jan 15;93(2):564-70 - PubMed
  360. Trans Am Clin Climatol Assoc. 2004;115:201-19 - PubMed
  361. EuroIntervention. 2009 Mar;4(5):662-8 - PubMed
  362. J Cell Physiol. 2011 Jan;226(1):46-51 - PubMed
  363. J Biol Chem. 2008 Dec 19;283(51):35419-27 - PubMed
  364. Platelets. 2011;22(5):380-4 - PubMed
  365. Blood. 2001 Mar 15;97(6):1727-32 - PubMed
  366. J Clin Apher. 2007 Feb;22(1):31-6 - PubMed
  367. JAMA. 2009 Aug 26;302(8):849-57 - PubMed
  368. Biochim Biophys Acta. 2004 Mar 22;1636(2-3):119-28 - PubMed
  369. Prog Hematol. 1987;15:91-113 - PubMed
  370. Miss Valley Med J. 1956 Sep;78(5):213-5 - PubMed
  371. Int J Cell Cloning. 1990 Jul;8(4):224-6 - PubMed
  372. J Lab Clin Med. 1968 Jan;71(1):153-65 - PubMed
  373. Thromb Diath Haemorrh. 1966 Jan 31;15(1):84-92 - PubMed
  374. Curr Opin Hematol. 2004 May;11(3):151-5 - PubMed
  375. Am Heart J. 2005 Nov;150(5):1015 - PubMed
  376. J Biol Chem. 2010 Oct 1;285(40):30370-4 - PubMed
  377. Lab Invest. 1967 Dec;17(6):616-44 - PubMed
  378. J Am Coll Cardiol. 2008 Apr 8;51(14):1404-11 - PubMed
  379. Circ Cardiovasc Interv. 2009 Jun;2(3):230-6 - PubMed
  380. J Lipid Res. 1978 Sep;19(7):793-826 - PubMed
  381. J Thromb Haemost. 2009 Jul;7 Suppl 1:24-7 - PubMed
  382. J Thromb Haemost. 2004 Oct;2(10):1681-90 - PubMed
  383. Curr Opin Immunol. 2010 Oct;22(5):634-42 - PubMed
  384. Blood. 2003 Dec 1;102(12):4044-51 - PubMed
  385. J Clin Invest. 1958 Dec;37(12):1836-47 - PubMed
  386. Blood. 1985 Apr;65(4):1021-4 - PubMed
  387. Nature. 2001 Jan 11;409(6817):202-7 - PubMed
  388. J Thromb Haemost. 2005 Jun;3(6):1119-24 - PubMed
  389. Am J Med. 1971 Dec;51(6):818-28 - PubMed
  390. Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2362-7 - PubMed

MeSH terms

Publication Types

Grant support