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Lehtonen A, Viikari J. Long-term effect of the combination of calcium clofibrate and calcium carbonate on serum total cholesterol, triglyceride and high density lipoprotein--cholesterol concentrations in hyperlipoproteinaemia. A comparative study with clofibrate. Atherosclerosis. 1979;33(1):49-58doi: 10.1016/0021-9150(79)90197-7.
Lehtonen, A., & Viikari, J. (1979). Long-term effect of the combination of calcium clofibrate and calcium carbonate on serum total cholesterol, triglyceride and high density lipoprotein--cholesterol concentrations in hyperlipoproteinaemia. A comparative study with clofibrate. Atherosclerosis, 33(1), 49-58. https://doi.org/10.1016/0021-9150(79)90197-7
Lehtonen, A, and Viikari, J. "Long-term effect of the combination of calcium clofibrate and calcium carbonate on serum total cholesterol, triglyceride and high density lipoprotein--cholesterol concentrations in hyperlipoproteinaemia. A comparative study with clofibrate." Atherosclerosis vol. 33,1 (1979): 49-58. doi: https://doi.org/10.1016/0021-9150(79)90197-7
Lehtonen A, Viikari J. Long-term effect of the combination of calcium clofibrate and calcium carbonate on serum total cholesterol, triglyceride and high density lipoprotein--cholesterol concentrations in hyperlipoproteinaemia. A comparative study with clofibrate. Atherosclerosis. 1979 May;33(1):49-58. doi: 10.1016/0021-9150(79)90197-7. PMID: 223601.
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Elsevier Science

Atherosclerosis. 1979 May;33(1):49-58. doi: 10.1016/0021-9150(79)90197-7.

Long-term effect of the combination of calcium clofibrate and calcium carbonate on serum total cholesterol, triglyceride and high density lipoprotein--cholesterol concentrations in hyperlipoproteinaemia. A comparative study with clofibrate.

Atherosclerosis

A Lehtonen, J Viikari

PMID: 223601 DOI: 10.1016/0021-9150(79)90197-7

Abstract

Thirty hyperlipidaemic patients (19 with type IIA, 4 with IIB and 7 with type IV hyperlipoproteinaemia) were subjected to therapy with calcium clofibrate and calcium carbonate (4C, 2 + 2 g/day for 6 months) and the effect was compared with clofibrate (1C, 2 g/day) which was given for 6 months as well, in a single-blind placebo-controlled study. 4C and 1C decreased total serum cholesterol levels especially in subgroups IIA and IIB. 4C was somewhat more effective than 1C in decreasing (VLDL + LDL)-cholesterol in subgroup IIA. The HDL-cholesterol concentrations and the ratio of HDL-cholesterol and total cholesterol increased during treatment with both 1C and 4C. The HDL-cholesterol increase (vs. placebo) was 18%. The concentrations of serum triglycerides decreased by 33% during both treatment periods and there was no significant difference between 1C and 4C.

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