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Conti I, Tridico RV, Caccia S. Effect of chronic oral delorazepam on in vitro and in vivo hepatic drug-metabolizing enzyme activities in the rat. Res Commun Chem Pathol Pharmacol. 1990;67(1):87-99
Conti, I., Tridico, R. V., & Caccia, S. (1990). Effect of chronic oral delorazepam on in vitro and in vivo hepatic drug-metabolizing enzyme activities in the rat. Research communications in chemical pathology and pharmacology, 67(1), 87-99.
Conti, I, et al. "Effect of chronic oral delorazepam on in vitro and in vivo hepatic drug-metabolizing enzyme activities in the rat." Research communications in chemical pathology and pharmacology vol. 67,1 (1990): 87-99.
Conti I, Tridico RV, Caccia S. Effect of chronic oral delorazepam on in vitro and in vivo hepatic drug-metabolizing enzyme activities in the rat. Res Commun Chem Pathol Pharmacol. 1990 Jan;67(1):87-99. PMID: 2109343.
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Res Commun Chem Pathol Pharmacol. 1990 Jan;67(1):87-99.

Effect of chronic oral delorazepam on in vitro and in vivo hepatic drug-metabolizing enzyme activities in the rat.

Research communications in chemical pathology and pharmacology

I Conti, R V Tridico, S Caccia

Affiliations

  1. Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.

PMID: 2109343

Abstract

In vivo (delorazepam clearance) and in vitro (monooxygenase activity markers) alterations in drug metabolism and the extent of enzyme induction of the hepatic cytochrome P-450 system were evaluated after oral administration of delorazepam (2.5, 25 and 150 mg/kg) for two weeks to male Sprague-Dawley rats. This benzodiazepine had no significant effect on drug metabolizing enzymes, except for slight enhancement of in vitro aniline p-hydroxylase activity which occurred at doses approximately 100 times those used clinically (0.5-2 mg). Under the likely conditions of exposure to delorazepam in human therapy therefore, such alteration in liver enzymes would be unlikely to have clinical relevance.

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