Display options
Share it on
Full text links
Nature Publishing Group Free PMC Article

Br J Cancer. 1990 Feb;61(2):298-302. doi: 10.1038/bjc.1990.56.

Hormone levels in older women: a study of post-menopausal breast cancer patients and healthy population controls.

British journal of cancer

L Bernstein, R K Ross, M C Pike, J B Brown, B E Henderson

Affiliations

  1. Department of Preventive Medicine, University of Southern California School of Medicine, Los Angeles 90033.

PMID: 2138030 PMCID: PMC1971424 DOI: 10.1038/bjc.1990.56
Free PMC Article

Abstract

Hormone concentrations in blood and total 12 h urine values were compared between 40 post-menopausal women with breast cancer and 40 control women in a study which carefully controlled for the possible confounding effects of age, weight and pregnancy history by individually matching cases and controls on these factors. Breast cancer cases had received only surgical treatment for their localised disease, which was diagnosed from 1 to 9 years before hormonal evaluation. Cases had 15% higher serum oestradiol levels (P = 0.02), 40% more urinary oestradiol (P = 0.03) and 44% more urinary oestriol (P = 0.04) than control women. Cases also had higher levels of serum and urinary oestrone, but these differences were not statistically significant. The percentages of serum oestradiol not bound to albumin or sex-hormone binding globulin did not differ between cases and controls, nor were there statistically significant differences in the serum levels of prolactin, sex-hormone binding globulin or dehydroepiandrosterone sulphate. These results provide further support for the hypothesis that breast cancer risk is determined in part by post-menopausal serum oestrogen concentration.

Similar articles

Cited by

Calaf GM, Urzua U, Termini L, Aguayo F.
Oncotarget. 2018 May 04;9(34):23824-23842. doi: 10.18632/oncotarget.25323. eCollection 2018 May 04.
PMID: 29805775

Medina-Diaz-Cortés G, Brancaccio-Pérez IV, Esparza-Estrada I, Barbosa-Camacho FJ, Fuentes-Orozco C, González-Hernández PG, Chejfec-Ciociano JM, Ramírez-Sánchez MV, Sánchez-López VA, Cortés-Flores AO, Álvarez-Villaseñor AS, Chávez-Tostado M, Cervantes-Pérez E, Cervantes-Guevara G, Cervantes-Cardona GA, González-Ojeda A.
World J Surg. 2022 Feb;46(2):356-361. doi: 10.1007/s00268-021-06367-y. Epub 2021 Nov 03.
PMID: 34731260

Medina-Diaz-Cortés G, Brancaccio-Pérez IV, Esparza-Estrada I, Barbosa-Camacho FJ, Fuentes-Orozco C, González-Hernández PG, Chejfec-Ciociano JM, Ramírez-Sánchez MV, Sánchez-López VA, Cortés-Flores AO, Álvarez-Villaseñor AS, Chávez-Tostado M, Cervantes-Pérez E, Cervantes-Guevara G, Cervantes-Cardona GA, González-Ojeda A.
World J Surg. 2021 Nov 03; doi: 10.1007/s00268-021-06367-y. Epub 2021 Nov 03.
PMID: 34731260

Medina-Diaz-Cortés G, Brancaccio-Pérez IV, Esparza-Estrada I, Barbosa-Camacho FJ, Fuentes-Orozco C, González-Hernández PG, Chejfec-Ciociano JM, Ramírez-Sánchez MV, Sánchez-López VA, Cortés-Flores AO, Álvarez-Villaseñor AS, Chávez-Tostado M, Cervantes-Pérez E, Cervantes-Guevara G, Cervantes-Cardona GA, González-Ojeda A.
World J Surg. 2022 Feb;46(2):356-361. doi: 10.1007/s00268-021-06367-y. Epub 2021 Nov 03.
PMID: 34731260

References

  1. Am J Epidemiol. 1985 Oct;122(4):579-88 - PubMed
  2. J Natl Cancer Inst. 1985 Apr;74(4):741-5 - PubMed
  3. Cancer. 1986 Feb 1;57(3):558-62 - PubMed
  4. J Natl Cancer Inst. 1986 Jun;76(6):1035-9 - PubMed
  5. Clin Endocrinol Metab. 1986 May;15(2):259-78 - PubMed
  6. Ann N Y Acad Sci. 1986;464:100-5 - PubMed
  7. Int J Cancer. 1986 Nov 15;38(5):625-30 - PubMed
  8. N Engl J Med. 1987 Jan 29;316(5):229-34 - PubMed
  9. Am J Epidemiol. 1987 May;125(5):791-9 - PubMed
  10. Cancer Res. 1988 Jan 15;48(2):246-53 - PubMed
  11. Eur J Cancer Clin Oncol. 1988 Jan;24(1):29-43 - PubMed
  12. Acta Endocrinol (Copenh). 1964 Sep;47:15-26 - PubMed
  13. Am J Obstet Gynecol. 1965 Jun 15;92:460-7 - PubMed
  14. Eur J Cancer. 1968 Oct;4(5):523-7 - PubMed
  15. J Natl Cancer Inst. 1972 Mar;48(3):605-13 - PubMed
  16. J Clin Endocrinol Metab. 1972 Jun;34(6):983-8 - PubMed
  17. Lancet. 1973 Jan 27;1(7796):165-8 - PubMed
  18. Am J Obstet Gynecol. 1973 Dec 1;117(7):962-70 - PubMed
  19. Am J Obstet Gynecol. 1974 Jan 15;118(2):173-8 - PubMed
  20. Clin Endocrinol (Oxf). 1974 Jan;3(1):69-96 - PubMed
  21. Br J Cancer. 1974 Dec;30(6):571-6 - PubMed
  22. Public Health Rep. 1975 Jan-Feb;90(1):15-7 - PubMed
  23. Am J Obstet Gynecol. 1975 Feb 15;121(4):496-500 - PubMed
  24. J Steroid Biochem. 1975 May;6(5):729-34 - PubMed
  25. Lancet. 1976 May 22;1(7969):1100-2 - PubMed
  26. Eur J Cancer. 1976 Dec;12(12):951-8 - PubMed
  27. Cancer Res. 1977 Dec;37(12):4655-9 - PubMed
  28. J Clin Invest. 1979 Jul;64(1):145-54 - PubMed
  29. J Natl Cancer Inst. 1979 Nov;63(5):1171-4 - PubMed
  30. JAMA. 1980 Apr 25;243(16):1635-9 - PubMed
  31. Ups J Med Sci. 1979;84(3):259-74 - PubMed
  32. J Steroid Biochem. 1980 Jul;13(7):793-802 - PubMed
  33. Obstet Gynecol. 1981 Jan;57(1):69-73 - PubMed
  34. Br J Cancer. 1981 Jun;43(6):826-31 - PubMed
  35. Int J Cancer. 1982 Jan 15;29(1):17-21 - PubMed
  36. Endocrinology. 1983 Feb;112(2):486-91 - PubMed
  37. Br J Cancer. 1983 Feb;47(2):269-75 - PubMed
  38. Cancer Res. 1983 Aug;43(8):3940-3 - PubMed
  39. Br J Cancer. 1985 Apr;51(4):479-84 - PubMed
  40. Int J Cancer. 1985 Apr 15;35(4):457-60 - PubMed
  41. J Natl Cancer Inst. 1985 Nov;75(5):823-9 - PubMed

Substances

MeSH terms

Publication Types

Grant support

LinkOut - more resources