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J Pediatr Gastroenterol Nutr. 1990 Apr;10(3):339-43. doi: 10.1097/00005176-199004000-00013.

Protein turnover in malnourished patients with cystic fibrosis: effects of elemental and nonelemental nutritional supplements.

Journal of pediatric gastroenterology and nutrition

J T Pelekanos, T L Holt, L C Ward, G J Cleghorn, R W Shepherd

Affiliations

  1. Department of Paediatric Gastroenterology and Nutrition, Royal Children's Hospital, Brisbane, Queensland, Australia.

PMID: 2109053 DOI: 10.1097/00005176-199004000-00013

Abstract

To evaluate the relative efficacy of nonelemental versus semielemental enteral supplements for nutritional rehabilitation of cystic fibrosis (CF) patients, whole-body protein turnover using the [15N]glycine method was studied in nine malnourished CF patients during enteral feedings, in a block design study comparing a semielemental formula (Criticare), a higher protein density but nonelemental formula (Traumacal) (T), and a nonelemental formula that had been modified to become isocaloric and isonitrogenous to the semielemental formula (modified Traumacal, MT). No significant differences in rates of protein synthesis or catabolism were observed comparing the three formulas. However, the higher protein density nonelemental formula resulted in higher net protein deposition compared to the other two formulas (T + 0.42 g kg-1 10 h-1 versus 0.33 g kg-1 10 h-1 for Criticare and -0.59 g kg-1 10 h-1 for MT), although this was significant (p less than 0.05) for the MT versus T comparison only. This study lends support to the use of less expensive nonelemental formulas for the nutritional management of malnourished patients with CF.

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