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Shono N, Higaki Y, Mori M, et al. Physiological levels of estradiol correlate with lipid / lipoprotein profiles in healthy men. Environ Health Prev Med. 1999;4(2):81-6doi: 10.1007/BF02931999.
Shono, N., Higaki, Y., Mori, M., & Nishizumi, M. (1999). Physiological levels of estradiol correlate with lipid / lipoprotein profiles in healthy men. Environmental health and preventive medicine, 4(2), 81-6. https://doi.org/10.1007/BF02931999
Shono, N, et al. "Physiological levels of estradiol correlate with lipid / lipoprotein profiles in healthy men." Environmental health and preventive medicine vol. 4,2 (1999): 81-6. doi: https://doi.org/10.1007/BF02931999
Shono N, Higaki Y, Mori M, Nishizumi M. Physiological levels of estradiol correlate with lipid / lipoprotein profiles in healthy men. Environ Health Prev Med. 1999 Jul;4(2):81-6. doi: 10.1007/BF02931999. PMID: 21432177; PMCID: PMC2723429.
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Environ Health Prev Med. 1999 Jul;4(2):81-6. doi: 10.1007/BF02931999.

Physiological levels of estradiol correlate with lipid / lipoprotein profiles in healthy men.

Environmental health and preventive medicine

N Shono, Y Higaki, M Mori, M Nishizumi

Affiliations

  1. Department of Community Health Science, Saga Medical School, Nabeshima 5-1-1, 849-8501, Saga, Japan.

PMID: 21432177 PMCID: PMC2723429 DOI: 10.1007/BF02931999

Abstract

In this cross-sectional study, the relationships of the physiological levels of estradiol (E2) and dehydroepiandrosterone-sulfate (DHEA-S) to the lipid and lipoprotein profiles were investigated in 212 apparently healthy men aged from 18 to 59 years old. These subjects were divided into tertiles according to the levels of E2 and DHEA-S, respectively. We performed one-way analysis of variance and analysis of co-variance controlling for age, body mass index, percent body fat, waist to hip ratio, maximal oxygen uptake, alcohol and cigarette consumptions as confounding factors.A lower E2 level was associated with higher concentrations of total cholesterol (TC) and low density lipoprotein cholesterol. A lower DHEA-S level was associated with a lower concentration of high density lipoprotein cholesterol (HDLC) and a higher ratio of TC / HDLC. These correlations remained significant after adjusting for the above confounding factors. Neither free testosterone nor sex hormone-binding globulin was associated with the lipids and lipoproteins. These results suggest that higher levels of E2 and DHEA-S, at least in physiological concentrations, are related to the favorable lipid and lipoprotein levels in men.

Keywords: Dehydroepiandrosterone-sulfate; Estradiol; Lipid metabolism; Men

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