Display options
Cite
Pambianco G, Costacou T, Strotmeyer E, et al. The assessment of clinical distal symmetric polyneuropathy in type 1 diabetes: a comparison of methodologies from the Pittsburgh Epidemiology of Diabetes Complications Cohort. Diabetes Res Clin Pract. 2011;92(2):280-7doi: 10.1016/j.diabres.2011.02.005.
Pambianco, G., Costacou, T., Strotmeyer, E., & Orchard, T. J. (2011). The assessment of clinical distal symmetric polyneuropathy in type 1 diabetes: a comparison of methodologies from the Pittsburgh Epidemiology of Diabetes Complications Cohort. Diabetes research and clinical practice, 92(2), 280-7. https://doi.org/10.1016/j.diabres.2011.02.005
Pambianco, G, et al. "The assessment of clinical distal symmetric polyneuropathy in type 1 diabetes: a comparison of methodologies from the Pittsburgh Epidemiology of Diabetes Complications Cohort." Diabetes research and clinical practice vol. 92,2 (2011): 280-7. doi: https://doi.org/10.1016/j.diabres.2011.02.005
Pambianco G, Costacou T, Strotmeyer E, Orchard TJ. The assessment of clinical distal symmetric polyneuropathy in type 1 diabetes: a comparison of methodologies from the Pittsburgh Epidemiology of Diabetes Complications Cohort. Diabetes Res Clin Pract. 2011 May;92(2):280-7. doi: 10.1016/j.diabres.2011.02.005. Epub 2011 Mar 15. PMID: 21411172; PMCID: PMC3140677.
Copy Download .nbib Format: NLM
Share it on

Diabetes Res Clin Pract. 2011 May;92(2):280-7. doi: 10.1016/j.diabres.2011.02.005. Epub 2011 Mar 15.

The assessment of clinical distal symmetric polyneuropathy in type 1 diabetes: a comparison of methodologies from the Pittsburgh Epidemiology of Diabetes Complications Cohort.

Diabetes research and clinical practice

G Pambianco, T Costacou, Elsa Strotmeyer, T J Orchard

Affiliations

  1. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States.

PMID: 21411172 PMCID: PMC3140677 DOI: 10.1016/j.diabres.2011.02.005

Abstract

Distal symmetrical polyneuropathy (DSP) is the most common type of diabetic neuropathy, but often difficult to diagnose reliably. We evaluated the cross-sectional association between three point-of-care devices, Vibratron II, NC-stat(®), and Neurometer(®), and two clinical protocols, MNSI and monofilament, in identifying those with DSP, and/or amputation/ulcer/neuropathic pain (AUP), the two outcomes of major concern. This report presents data from 195 type 1 diabetic participants of the Epidemiology of Diabetes Complications (EDC) Study attending the 18-year examination (2004-2006). Participants with physician-diagnosed DSP, AUP or who were abnormal on the NC-stat, and the Vibratron II, MNSI, and monofilament were older (p<0.05) and had a longer duration of diabetes (p < 0.05). There was no difference by sex for DSP, AUP, or any testing modality, with the exception of NCstat (motor). The Vibratron II and MNSI showed the highest sensitivity for DSP (>87%) and AUP (>80%), whereas the monofilament had the highest specificity (98% DSP, 94% AUP) and positive predictive value (89% DSP, 47% AUP), but lowest sensitivity (20% DSP, 30% AUP). The MNSI also had the highest negative predictive value (83%) and Youden's Index (37%) and currently presents the single best combination of sensitivity and specificity of DSP in type 1 diabetes.

Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

References

  1. Diabetologia. 1996 Nov;39(11):1377-84 - PubMed
  2. Diabetologia. 2000 Aug;43(8):957-73 - PubMed
  3. Diabetes Care. 1989 Apr;12(4):270-5 - PubMed
  4. Clin Neurol Neurosurg. 2006 Jul;108(5):477-81 - PubMed
  5. Diabetes Care. 1997 May;20(5):836-43 - PubMed
  6. Pediatr Diabetes. 2010 Dec;11(8):521-8 - PubMed
  7. Clin Chem. 1983 Jun;29(6):1075-80 - PubMed
  8. Clin Chem. 1982 Jun;28(6):1379-88 - PubMed
  9. Diabet Med. 2009 Apr;26(4):391-6 - PubMed
  10. Diabetes Care. 2003 Jun;26(6):1790-5 - PubMed
  11. Diabetes Care. 2000 May;23(5):606-11 - PubMed
  12. Clin Cornerstone. 2003;5(2):38-55 - PubMed
  13. Neurology. 1993 Apr;43(4):817-24 - PubMed
  14. Diabetes. 2000 Apr;49(4):626-32 - PubMed
  15. Diabetes Care. 1992 Aug;15(8):1081-3 - PubMed
  16. Electromyogr Clin Neurophysiol. 2008 Nov-Dec;48(8):351-7 - PubMed
  17. Metabolism. 2006 Dec;55(12):1689-96 - PubMed
  18. Ann Neurol. 1995 Dec;38(6):869-80 - PubMed
  19. Ann N Y Acad Sci. 2006 Nov;1084:304-18 - PubMed
  20. Am Fam Physician. 2005 Jun 1;71(11):2123-8 - PubMed
  21. Diabetes. 1982 Feb;31(2):136-44 - PubMed
  22. Diabetes. 1997 Apr;46(4):665-70 - PubMed
  23. Diabetes Care. 2008 Mar;31(3):522-4 - PubMed
  24. Diabetes Care. 2006 Jun;29(6):1202-7 - PubMed
  25. J Intern Med. 1999 Jul;246(1):97-103 - PubMed
  26. Diabetes Care. 1988 Jul-Aug;11(7):592-7 - PubMed
  27. Neurology. 1996 Jan;46(1):85-91 - PubMed
  28. Diabetes Care. 2006 Sep;29(9):2023-7 - PubMed
  29. Diabetes Care. 1999 Jul;22(7):1036-42 - PubMed
  30. Diabetes Care. 1999 Jul;22(7):1029-35 - PubMed
  31. Nephron. 1976;16(1):31-41 - PubMed
  32. Clin Chem. 1974 Apr;20(4):470-5 - PubMed
  33. Diabetes Care. 2004 Jul;27(7):1610-7 - PubMed
  34. Diabetes Care. 1994 Nov;17(11):1281-9 - PubMed
  35. Metabolism. 2002 Feb;51(2):248-54 - PubMed
  36. Diabetes. 2000 Sep;49(9):1571-8 - PubMed
  37. Diabetes. 1990 Sep;39(9):1116-24 - PubMed
  38. Diabetes Care. 2005 Apr;28(4):956-62 - PubMed
  39. Clin Chem. 1982 Oct;28(10):2077-80 - PubMed
  40. Diabetes Res Clin Pract. 2005 Nov;70(2):143-50 - PubMed
  41. Prev Med. 1976 Jun;5(2):207-15 - PubMed
  42. Intern Med. 2002 Dec;41(12):1079-80 - PubMed
  43. Del Med J. 1991 Feb;63(2):85-93 - PubMed
  44. Phys Ther. 1996 Jan;76(1):68-71 - PubMed
  45. Diabetes. 1989 Nov;38(11):1456-61 - PubMed

MeSH terms

Publication Types

Grant support