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Casto DT, Schnapf BM, Clotz MA. Lack of effect of short-term passive smoking on the metabolic disposition of theophylline. Eur J Clin Pharmacol. 1990;39(4):399-402doi: 10.1007/BF00315418.
Casto, D. T., Schnapf, B. M., & Clotz, M. A. (1990). Lack of effect of short-term passive smoking on the metabolic disposition of theophylline. European journal of clinical pharmacology, 39(4), 399-402. https://doi.org/10.1007/BF00315418
Casto, D T, et al. "Lack of effect of short-term passive smoking on the metabolic disposition of theophylline." European journal of clinical pharmacology vol. 39,4 (1990): 399-402. doi: https://doi.org/10.1007/BF00315418
Casto DT, Schnapf BM, Clotz MA. Lack of effect of short-term passive smoking on the metabolic disposition of theophylline. Eur J Clin Pharmacol. 1990;39(4):399-402. doi: 10.1007/BF00315418. PMID: 2076725.
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Eur J Clin Pharmacol. 1990;39(4):399-402. doi: 10.1007/BF00315418.

Lack of effect of short-term passive smoking on the metabolic disposition of theophylline.

European journal of clinical pharmacology

D T Casto, B M Schnapf, M A Clotz

Affiliations

  1. Department of Pharmacology, University of Texas Health Science Center, San Antonio.

PMID: 2076725 DOI: 10.1007/BF00315418

Abstract

To test the hypothesis that involuntary smoking can result in increased drug metabolism, five nonsmoking healthy male volunteers (21-36 y old) were enrolled in a study of single-dose theophylline pharmacokinetics before and after intense environmental tobacco smoke (ETS) exposure. Exposure was provided by spending 3 h/day for five consecutive days in a small room with a smoking apparatus that burned four cigarettes simultaneously, at a rate of 20 cigarettes/h. Measurement of urine continine concentration demonstrated that significant absorption from ETS occurred in all subjects. However, pre- and post-exposure pharmacokinetic parameters for theophylline did not differ significantly: Vz = 0.438 vs 0.440 l.kg-1; t1/2 = 9.19 vs 9.69 h; CL = 34.4 vs 32.6 (ml.kg-1.h-1), respectively. Similarly, 24-hr urinary excretion of theophylline and its metabolites was unchanged by ETS exposure. We conclude that intense short-term passive smoking does not affect theophylline disposition. The possibility of chronic ETS exposure causing alterations in drug metabolism cannot be excluded.

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