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Dionne S, Russo P, Tuchweber B, et al. Cholic acid and chenodeoxycholic acid transport in the hepatic acinus in rats. Effect of necrosis of zone 3 induced by bromobenzene. Liver. 1990;10(6):336-42doi: 10.1111/j.1600-0676.1990.tb00478.x.
Dionne, S., Russo, P., Tuchweber, B., Plaa, G. L., & Yousef, I. M. (1990). Cholic acid and chenodeoxycholic acid transport in the hepatic acinus in rats. Effect of necrosis of zone 3 induced by bromobenzene. Liver, 10(6), 336-42. https://doi.org/10.1111/j.1600-0676.1990.tb00478.x
Dionne, S, et al. "Cholic acid and chenodeoxycholic acid transport in the hepatic acinus in rats. Effect of necrosis of zone 3 induced by bromobenzene." Liver vol. 10,6 (1990): 336-42. doi: https://doi.org/10.1111/j.1600-0676.1990.tb00478.x
Dionne S, Russo P, Tuchweber B, Plaa GL, Yousef IM. Cholic acid and chenodeoxycholic acid transport in the hepatic acinus in rats. Effect of necrosis of zone 3 induced by bromobenzene. Liver. 1990 Dec;10(6):336-42. doi: 10.1111/j.1600-0676.1990.tb00478.x. PMID: 2074731.
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Liver. 1990 Dec;10(6):336-42. doi: 10.1111/j.1600-0676.1990.tb00478.x.

Cholic acid and chenodeoxycholic acid transport in the hepatic acinus in rats. Effect of necrosis of zone 3 induced by bromobenzene.

Liver

S Dionne, P Russo, B Tuchweber, G L Plaa, I M Yousef

Affiliations

  1. Pediatric Research Center, Hôpital Sainte-Justine, Montreal, Quebec, Canada.

PMID: 2074731 DOI: 10.1111/j.1600-0676.1990.tb00478.x

Abstract

The transport of cholic acid (CA) and chenodeoxycholic acid (CDC) and their influence on bile formation was investigated in rats treated with bromobenzene (BZ), a toxicant which selectively destroys zone 3 of the hepatic acinus. The necrosis equals 27-31% of the acinus cells. The absence of zone 3 in rats reduced the secretory rate maximum of CA and CDC by 18% (NS) and 25% (p less than 0.05), respectively. The maximum bile flow was not different from control during CA infusion but was lower during CDC infusion in BZ-treated animals. Although the bile acid concentration was lower in BZ-treated rats, only values obtained during the basal period and the beginning of the infusion reached the level of statistically significant difference. The bile salt-independent flow (BSIF) was not affected by the absence of zone 3. Our data suggest that zones 1 and 2 of the hepatic acinus can compensate for the secretion of CA and elaboration of BSIF when zone 3 is destroyed. However, necrosis of zone 3 reduces CDC secretion. Thus, the capacity for bile acid transport of the hepatocytes of different zones in the hepatic acinus may differ according to the circulating bile acid.

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