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Donti E, Tabilio A, Bocchini F, et al. Partial trisomy 1q in idiopathic myelofibrosis. Leuk Res. 1990;14(11):1035-40doi: 10.1016/0145-2126(90)90117-r.
Donti, E., Tabilio, A., Bocchini, F., Falzetti, F., Martelli, M. F., Grignani, F., & Donti, G. V. (1990). Partial trisomy 1q in idiopathic myelofibrosis. Leukemia research, 14(11), 1035-40. https://doi.org/10.1016/0145-2126(90)90117-r
Donti, E, et al. "Partial trisomy 1q in idiopathic myelofibrosis." Leukemia research vol. 14,11 (1990): 1035-40. doi: https://doi.org/10.1016/0145-2126(90)90117-r
Donti E, Tabilio A, Bocchini F, Falzetti F, Martelli MF, Grignani F, Donti GV. Partial trisomy 1q in idiopathic myelofibrosis. Leuk Res. 1990;14(11):1035-40. doi: 10.1016/0145-2126(90)90117-r. PMID: 2280601.
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Leuk Res. 1990;14(11):1035-40. doi: 10.1016/0145-2126(90)90117-r.

Partial trisomy 1q in idiopathic myelofibrosis.

Leukemia research

E Donti, A Tabilio, F Bocchini, F Falzetti, M F Martelli, F Grignani, G V Donti

Affiliations

  1. Istituto di Clinica Medica I, Università di Perugia, Italy.

PMID: 2280601 DOI: 10.1016/0145-2126(90)90117-r

Abstract

Three cases of idiopathic myelofibrosis with partial trisomy of the long arm of chromosome 1 are described. Partial trisomy 1q was the only karyotypic change detectable in unstimulated peripheral blood cell cultures of one and bone-marrow cultures of two patients at diagnosis. The extra segment from chromosome 1 was located on different karyotype sites, i.e. 1qter, 1p34 and 6p22-23; 1q21-32 was the shortest overlapping region and the only trisomic segment in one of the three patients. These findings suggest that partial trisomy 1q is a primary chromosome aberration in myelofibrosis relevant in the pathogenesis of this hematologic disorder.

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