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Khan S, Abuzakouk M, Doré PC, et al. Administering intravenous immunoglobulin during infection is associated with infusion reactions in selected patients. Ir J Med Sci. 2010;180(1):125-8doi: 10.1007/s11845-010-0654-4.
Khan, S., Abuzakouk, M., Doré, P. C., & Sewell, W. A. (2011). Administering intravenous immunoglobulin during infection is associated with infusion reactions in selected patients. Irish journal of medical science, 180(1), 125-8. https://doi.org/10.1007/s11845-010-0654-4
Khan, S, et al. "Administering intravenous immunoglobulin during infection is associated with infusion reactions in selected patients." Irish journal of medical science vol. 180,1 (2011): 125-8. doi: https://doi.org/10.1007/s11845-010-0654-4
Khan S, Abuzakouk M, Doré PC, Sewell WA. Administering intravenous immunoglobulin during infection is associated with infusion reactions in selected patients. Ir J Med Sci. 2011 Mar;180(1):125-8. doi: 10.1007/s11845-010-0654-4. Epub 2010 Dec 07. PMID: 21136195.
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Ir J Med Sci. 2011 Mar;180(1):125-8. doi: 10.1007/s11845-010-0654-4. Epub 2010 Dec 07.

Administering intravenous immunoglobulin during infection is associated with infusion reactions in selected patients.

Irish journal of medical science

S Khan, M Abuzakouk, P C Doré, W A C Sewell

Affiliations

  1. Department of Immunology, Frimley Park Hospital NHS Foundation Trust, Frimley, Camberley, Surrey, GU16 7UJ, UK. [email protected]

PMID: 21136195 DOI: 10.1007/s11845-010-0654-4

Abstract

BACKGROUND: Guidelines vary regarding the safety of administering intravenous immunoglobulin (IVIG) during infections, although evidence for this advice is lacking and is based on expert opinion.

AIMS: We retrospectively studied patients with common variable immunodeficiency who reacted during IVIG therapy as to whether routinely obtained markers of infection such as C-reactive protein (CRP) were elevated.

METHODS: 19 patients on replacement IVIG therapy in a hospital-based infusion unit were studied. CRP levels obtained were normalized to baseline levels without reactions (defined as 100).

RESULTS: 8 of 19 patients had 16 reactions over a total of 107 infusions. Normalized CRP levels during reactions were higher [mean (±SD) of 258 (±215)] than during infusions with no reaction [mean 100 (±54.9), p = 0.017], and higher than in patients who did not react [mean 100 (±79.7), p = 0.017].

CONCLUSIONS: Some patients with IVIG reactions had elevated CRP levels suggesting that concurrent infection may have caused the reaction. Pre-emptive antibiotic therapy and delaying infusion could prevent unnecessary morbidity.

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