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Elsevier Science

Pharmacol Biochem Behav. 1990 Apr;35(4):865-9. doi: 10.1016/0091-3057(90)90372-o.

Enantiomers of phenylpropanolamine suppress food intake in hyperphagic rats.

Pharmacology, biochemistry, and behavior

M S Eisenberg, T J Maher

Affiliations

  1. Department of Pharmacology, Massachusetts College of Pharmacy and Allied Health Sciences, Boston 02115.

PMID: 2189144 DOI: 10.1016/0091-3057(90)90372-o

Abstract

Phenylpropanolamine (PPA, d,l-norephedrine), available in many over-the-counter nasal decongestants and appetite suppressants, is a racemic mixture of the enantiomers d- and l-norephedrine. The present study evaluates the effects of the individual PPA enantiomers on a variety of nondrug (food deprivation) and drug-induced hyperphagias (2-deoxyglucose and insulin). Racemic PPA has been shown to significantly suppress food intake in these hyperphagic models. Both l-norephedrine (5-50 mg/kg) and d-norephedrine (5-150 mg/kg), administered intraperitoneally, significantly suppressed feeding after a 4-hr fast during the dark cycle. During the light period, l-norephedrine (7.5, 10, 15 mg/kg) and d-norephedrine (75, 100, 150 mg/kg) significantly reduced food intake at the 1-hr and 3-hr time intervals in the 24-hr food deprivation-, insulin- and 2-deoxyglucose-induced hyperphagic models. Only 7.5 mg/kg l-norephedrine in the insulin-induced hyperphagia at 3 hr failed to significantly suppress feeding. These results indicate that each individual PPA enantiomer possesses the ability to suppress food intake in rats made hyperphagic by various stimuli.

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