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Malik M, Poloniecki J, Camm AJ. Changes in the distribution of ventricular ectopic beats in long-term electrocardiograms. Med Biol Eng Comput. 1990;28(5):423-30doi: 10.1007/BF02441965.
Malik, M., Poloniecki, J., & Camm, A. J. (1990). Changes in the distribution of ventricular ectopic beats in long-term electrocardiograms. Medical & biological engineering & computing, 28(5), 423-30. https://doi.org/10.1007/BF02441965
Malik, M, et al. "Changes in the distribution of ventricular ectopic beats in long-term electrocardiograms." Medical & biological engineering & computing vol. 28,5 (1990): 423-30. doi: https://doi.org/10.1007/BF02441965
Malik M, Poloniecki J, Camm AJ. Changes in the distribution of ventricular ectopic beats in long-term electrocardiograms. Med Biol Eng Comput. 1990 Sep;28(5):423-30. doi: 10.1007/BF02441965. PMID: 2277542.
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Med Biol Eng Comput. 1990 Sep;28(5):423-30. doi: 10.1007/BF02441965.

Changes in the distribution of ventricular ectopic beats in long-term electrocardiograms.

Medical & biological engineering & computing

M Malik, J Poloniecki, A J Camm

Affiliations

  1. Department of Cardiological Sciences, St George's Hospital Medical School, London, UK.

PMID: 2277542 DOI: 10.1007/BF02441965

Abstract

Only simple methods have been used to assess antiarrhythmic and proarrhythmic effects when comparing baseline and on-therapy Holter recordings taken from the same patient. The paper suggests a new method for definition of these effects based upon comparisons of statistical distributions of ectopic beats. The method is based on multiple random sampling of the recordings and on application of the Smirnov test to compare the samplings. The results of these multiple comparisons are subsequently evaluated using the chi-squared test. An analysis is reported of Holter recordings made on seven patients suffering from ventricular arrhythmia but with anatomically normal heart. In each patient, one baseline recording and one recording on each of three different drugs were made. The results show that the definition of proarrhythmic effects can be partly addressed in a precise mathematical way. The method can also detect a significant change in the character of arrhythmia which can neither be classified as antiarrhythmic nor as proarrhythmic.

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