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Can Fam Physician. 1982 Dec;28:2204-7.

Pyrexia of unknown origin: an approach to diagnosis and management.

Canadian family physician Medecin de famille canadien

J C Gibson

PMID: 20469388 PMCID: PMC2306656

Abstract

Fever of unknown origin is one of the supreme diagnostic challenges in medicine. Most cases are caused by common problems presenting in unusual ways. Infections account for 40%, neoplasms 20% and collagen vascular diseases 15% of cases. Repeated clinical evaluation and individualization in planning investigative procedures are the keys to early diagnosis. Several possible causes of pyrexia are discussed.

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