Display options
Cite
Thomas KD, Adhikari AV, Shetty NS. Design, synthesis and antimicrobial activities of some new quinoline derivatives carrying 1,2,3-triazole moiety. Eur J Med Chem. 2010;45(9):3803-10doi: 10.1016/j.ejmech.2010.05.030.
Thomas, K. D., Adhikari, A. V., & Shetty, N. S. (2010). Design, synthesis and antimicrobial activities of some new quinoline derivatives carrying 1,2,3-triazole moiety. European journal of medicinal chemistry, 45(9), 3803-10. https://doi.org/10.1016/j.ejmech.2010.05.030
Thomas, K D, et al. "Design, synthesis and antimicrobial activities of some new quinoline derivatives carrying 1,2,3-triazole moiety." European journal of medicinal chemistry vol. 45,9 (2010): 3803-10. doi: https://doi.org/10.1016/j.ejmech.2010.05.030
Thomas KD, Adhikari AV, Shetty NS. Design, synthesis and antimicrobial activities of some new quinoline derivatives carrying 1,2,3-triazole moiety. Eur J Med Chem. 2010 Sep;45(9):3803-10. doi: 10.1016/j.ejmech.2010.05.030. Epub 2010 May 20. PMID: 20542604.
Copy Download .nbib Format: NLM
Share it on

Eur J Med Chem. 2010 Sep;45(9):3803-10. doi: 10.1016/j.ejmech.2010.05.030. Epub 2010 May 20.

Design, synthesis and antimicrobial activities of some new quinoline derivatives carrying 1,2,3-triazole moiety.

European journal of medicinal chemistry

K D Thomas, Airody Vasudeva Adhikari, N Suchetha Shetty

Affiliations

  1. Anthem Biosciences Pvt. Ltd, No. 49, Bommasandra Industrial Area, Bommasandra, Bangalore 560099, Karnataka, India.

PMID: 20542604 DOI: 10.1016/j.ejmech.2010.05.030

Abstract

A new series of [1-(6-methoxy-2-methylquinolin-4-yl)-1H-1,2,3-triazol-4-yl] methanamine derivatives were synthesized starting from 4-methoxyaniline through multi-step reactions. The title compounds 5a-y were prepared by treating the azide intermediate 4 with propargyl bromide and different alkyl/heterocyclic amines in a sequential three component synthesis. All the new compounds were characterized by spectral and elemental analyses. The newly synthesized final compounds were evaluated for their in vitro antibacterial and antifungal activities against pathogenic strains. The preliminary screening results indicated that most of the compounds demonstrated moderate to very good antibacterial and antifungal activities, comparable to the first-line drugs.

2010 Elsevier Masson SAS. All rights reserved.

Substances

MeSH terms

Publication Types