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Pollard AE, Barr RC. A biophysical model for cardiac microimpedance measurements. Am J Physiol Heart Circ Physiol. 2010;298(6):H1699-709doi: 10.1152/ajpheart.01131.2009.
Pollard, A. E., & Barr, R. C. (2010). A biophysical model for cardiac microimpedance measurements. American journal of physiology. Heart and circulatory physiology, 298(6), H1699-709. https://doi.org/10.1152/ajpheart.01131.2009
Pollard, Andrew E, and Barr, Roger C. "A biophysical model for cardiac microimpedance measurements." American journal of physiology. Heart and circulatory physiology vol. 298,6 (2010): H1699-709. doi: https://doi.org/10.1152/ajpheart.01131.2009
Pollard AE, Barr RC. A biophysical model for cardiac microimpedance measurements. Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H1699-709. doi: 10.1152/ajpheart.01131.2009. Epub 2010 Apr 02. PMID: 20363889; PMCID: PMC2886637.
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Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H1699-709. doi: 10.1152/ajpheart.01131.2009. Epub 2010 Apr 02.

A biophysical model for cardiac microimpedance measurements.

American journal of physiology. Heart and circulatory physiology

Andrew E Pollard, Roger C Barr

Affiliations

  1. Cardiac Rhythm Management Laboratory, Univ. of Alabama at Birmingham, Volker Hall B140, 1670 Univ. Blvd., Birmingham, AL 35294. [email protected]

PMID: 20363889 PMCID: PMC2886637 DOI: 10.1152/ajpheart.01131.2009

Abstract

Alterations to cell-to-cell electrical conductance and to the structural arrangement of the collagen network in cardiac tissue are recognized contributors to arrhythmia development, yet no present method allows direct in vivo measurements of these conductances at their true microscopic scale. The present report documents such a plan, which involves interstitial multisite stimulation at a subcellular to cellular size scale, and verifies the performance of the method through biophysical modeling. Although elements of the plan have been analyzed previously, their performance as a whole is considered here in a comprehensive way. Our analyses take advantage of a three-dimensional structural framework in which interstitial, intracellular, and membrane components are coupled to one another on the fine size scale, and electrodes are separated from one another as in arrays we fabricate routinely. With this arrangement, determination of passive tissue resistances can be made from measurements taken on top of the currents flowing in active tissue. In particular, our results show that measurements taken at multiple frequencies and electrode separations provide powerful predictions of the underlying tissue resistances in all geometric dimensions. Because of the small electrode size, separation of interstitial from intracellular compartment contributions is readily achieved.

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