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Kanasi E, Johansson I, Lu SC, et al. Microbial risk markers for childhood caries in pediatricians' offices. J Dent Res. 2010;89(4):378-83doi: 10.1177/0022034509360010.
Kanasi, E., Johansson, I., Lu, S. C., Kressin, N. R., Nunn, M. E., Kent, R., & Tanner, A. C. (2010). Microbial risk markers for childhood caries in pediatricians' offices. Journal of dental research, 89(4), 378-83. https://doi.org/10.1177/0022034509360010
Kanasi, E, et al. "Microbial risk markers for childhood caries in pediatricians' offices." Journal of dental research vol. 89,4 (2010): 378-83. doi: https://doi.org/10.1177/0022034509360010
Kanasi E, Johansson I, Lu SC, Kressin NR, Nunn ME, Kent R, Tanner AC. Microbial risk markers for childhood caries in pediatricians' offices. J Dent Res. 2010 Apr;89(4):378-83. doi: 10.1177/0022034509360010. Epub 2010 Feb 17. PMID: 20164496; PMCID: PMC2880172.
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J Dent Res. 2010 Apr;89(4):378-83. doi: 10.1177/0022034509360010. Epub 2010 Feb 17.

Microbial risk markers for childhood caries in pediatricians' offices.

Journal of dental research

E Kanasi, I Johansson, S C Lu, N R Kressin, M E Nunn, R Kent, A C R Tanner

Affiliations

  1. Department of Molecular Genetics, The Forsyth Institute, 140 The Fenway, Boston, MA 02115, USA.

PMID: 20164496 PMCID: PMC2880172 DOI: 10.1177/0022034509360010

Abstract

Dental caries in pre-school children has significant public health and health disparity implications. To determine microbial risk markers for this infection, this study aimed to compare the microbiota of children with early childhood caries with that of caries-free children. Plaque samples from incisors, molars, and the tongue from 195 children attending pediatricians' offices were assayed by 74 DNA probes and by PCR to Streptococcus mutans. Caries-associated factors included visible plaque, child age, race, and snacking habits. Species were detected more frequently from tooth than tongue samples. Lactobacillus gasseri (p < 0.01), Lactobacillus fermentum, Lactobacillus vaginalis, and S. mutans with Streptococcus sobrinus (all p < 0.05) were positively associated with caries. By multifactorial analysis, the probiotic Lactobacillus acidophilus was negatively associated with caries. Prevotella nigrescens was the only species (p < 0.05) significantly associated with caries by the 'false discovery' rate. Analysis of the data suggests that selected Lactobacillus species, in addition to mutans streptococci, are risk markers for early childhood caries.

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