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Tenore A, Franzese A, Quattrin T, et al. Prognostic signs in the evolution of premature thelarche by discriminant analysis. J Endocrinol Invest. 1991;14(5):375-81doi: 10.1007/BF03349086.
Tenore, A., Franzese, A., Quattrin, T., Sandomenico, M. L., Aloi, G., Gallo, P., Mariano, A., & Di Maio, S. (1991). Prognostic signs in the evolution of premature thelarche by discriminant analysis. Journal of endocrinological investigation, 14(5), 375-81. https://doi.org/10.1007/BF03349086
Tenore, A, et al. "Prognostic signs in the evolution of premature thelarche by discriminant analysis." Journal of endocrinological investigation vol. 14,5 (1991): 375-81. doi: https://doi.org/10.1007/BF03349086
Tenore A, Franzese A, Quattrin T, Sandomenico ML, Aloi G, Gallo P, Mariano A, Di Maio S. Prognostic signs in the evolution of premature thelarche by discriminant analysis. J Endocrinol Invest. 1991 May;14(5):375-81. doi: 10.1007/BF03349086. PMID: 1908492.
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J Endocrinol Invest. 1991 May;14(5):375-81. doi: 10.1007/BF03349086.

Prognostic signs in the evolution of premature thelarche by discriminant analysis.

Journal of endocrinological investigation

A Tenore, A Franzese, T Quattrin, M L Sandomenico, G Aloi, P Gallo, A Mariano, S Di Maio

Affiliations

  1. Dipartimento di Pediatria, II Facoltà di Medicina, Università di Napoli, Italy.

PMID: 1908492 DOI: 10.1007/BF03349086

Abstract

Since premature thelarche (PT) can be a first sign of precocious puberty (PP), the aim of our study was to identify simple items in the course of the first 6 months of follow-up that could help predict if PT would evolve to PP. Thirty-two girls with PT were studied. First evaluation included bone age (BA), basal estradiol, FSH, LH and prolactin. GnRH was performed in 15 subjects and BA was checked at 6 month intervals in 30. Based on clinical outcome after a mean follow-up of 33.4 +/- 16.5 (SD) months, patients were divided into 2 groups: Group I (G-I) included subjects whose breast development either remained unchanged, increased or regressed; Group II (G-II) included subjects who progressed to PP. The multivariate combination of the items which was able to best discriminate between the two groups was chosen in predicting the evolution of PT. The items considered included four variables available at the time of diagnosis [chronological (CA) at onset less than 3 years, basal FSH, basal LH and BA/CA ratio] and two additional variables after a 6-month follow-up (delta BA/delta CA and growth velocity); 88% of G-I and 14% of G-II had CA less than 3 yr. Basal FSH levels were elevated in both G-I (7.6 +/- 3.0 mIU/ml) and G-II (12.1 +/- 4.1) with respect to controls (2.6 +/- 1.2); however, approximately 20% of G-I had low FSH levels. Basal LH levels were consistently higher in G-II (8.0 +/- 1.3 mIU/ml) than in G-I (2.9 +/- 1.5) or controls (2.8 +/- 1.2). Although initial BA was advanced (greater than 2SD) in 21% of G-I and in all of G-II, an acceleration of BA was seen only in G-II. The mean growth velocity of G-I (44.1 +/- 31.5%) was significantly less than G-II (92 +/- 32%; p less than 0.0025). With the help of the discriminant equations derived from data obtained at diagnosis and during the first 6 months of follow-up, all subjects with isolated premature thelarche could be sharply distinguished from those who subsequently progressed to precocious puberty.(ABSTRACT TRUNCATED AT 250 WORDS)

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