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Nikkels A, Ben Mosbah T, Piérard-Franchimont C, et al. Comparative morphometric study of eruptive PUVA-induced and chronic sun-induced lentigines of the skin. Anal Quant Cytol Histol. 1991;13(1):23-6
Nikkels, A., Ben Mosbah, T., Piérard-Franchimont, C., de la Brassinne, M., & Piérard, G. E. (1991). Comparative morphometric study of eruptive PUVA-induced and chronic sun-induced lentigines of the skin. Analytical and quantitative cytology and histology, 13(1), 23-6.
Nikkels, A, et al. "Comparative morphometric study of eruptive PUVA-induced and chronic sun-induced lentigines of the skin." Analytical and quantitative cytology and histology vol. 13,1 (1991): 23-6.
Nikkels A, Ben Mosbah T, Piérard-Franchimont C, de la Brassinne M, Piérard GE. Comparative morphometric study of eruptive PUVA-induced and chronic sun-induced lentigines of the skin. Anal Quant Cytol Histol. 1991 Feb;13(1):23-6. PMID: 2025370.
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Anal Quant Cytol Histol. 1991 Feb;13(1):23-6.

Comparative morphometric study of eruptive PUVA-induced and chronic sun-induced lentigines of the skin.

Analytical and quantitative cytology and histology

A Nikkels, T Ben Mosbah, C Piérard-Franchimont, M de la Brassinne, G E Piérard

Affiliations

  1. Department of Dermatopathology, University of Liege, Belgium.

PMID: 2025370

Abstract

Computerized image analysis was used to compare lentigines (brown freckle-like cutaneous spots) induced by treatment with psoralens and ultraviolet light A (PUVA-induced lentigines) with those induced by solar exposure (actinic lentigines). For these conditions, which appear to be distinctive clinically and histologically, the number, size and shape of the macules were analyzed, revealing significant differences in the two latter parameters. This indicates that UV irradiations of different wave lengths act differently on melanocytes and/or on the interrelation between melanocytes and keratinocytes. The overall effect is much more self-limited in PUVA lentigines than in actinic lentigines, suggesting that the pathophysiology of these lesions is probably different.

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