J Am Coll Cardiol. 1991 Feb;17(2):519-26. doi: 10.1016/s0735-1097(10)80125-1.

Comparison of indium-111 antimyosin antibody and technetium-99m pyrophosphate localization in reperfused and nonreperfused myocardial infarction.

Journal of the American College of Cardiology

K Takeda, N D LaFrance, H F Weisman, H N Wagner, L C Becker

PMID: 1846888 DOI: 10.1016/s0735-1097(10)80125-1
Free Article

Abstract

Recent imaging studies suggest that technetium-99m (Tc-99m) pyrophosphate yields a considerably larger estimate of myocardial infarct size than does indium-111 (In-111) monoclonal antimyosin antibody. To determine whether Tc-99m pyrophosphate may be taken up by reversibly injured myocytes, particularly in the setting of coronary reperfusion, the tissue localization of Tc-99m pyrophosphate and antimyosin antibody was compared in 11 dogs 24 to 68 h after anterior descending coronary artery occlusion (4 dogs with permanent occlusion, 7 with reperfusion). Technetium-99m pyrophosphate and In-111 antimyosin antibody content was determined in serial 2 to 3 mm wide endocardial and epicardial samples taken through the infarct zone in multiple short-axis left ventricular slices. The number of samples with increased In-111 antimyosin antibody (defined as greater than or equal to mean + 2 SD of normal) was not significantly different from that with increased Tc-99m pyrophosphate. This was true in both reperfused and nonreperfused infarcts. However, the intensity of uptake of Tc-99m pyrophosphate exceeded that of In-111 antimyosin antibody, particularly in the border zones of reperfused infarcts, and the area with moderate to marked increase in tracer uptake (greater than or equal to 2 times normal) was significantly larger with Tc-99m pyrophosphate than In-111 antimyosin antibody (p less than 0.001). A specific zone of abnormal Tc-99m pyrophosphate with normal In-111 antimyosin antibody content could not be identified. Histologic evidence of myocardial necrosis was found in virtually every sample with increased In-111 antimyosin antibody, Tc-99m pyrophosphate, or both.(ABSTRACT TRUNCATED AT 250 WORDS)

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Substances

• Antibodies, Monoclonal
• Diphosphates
• Indium Radioisotopes
• Organometallic Compounds
• imciromab pentetate
• Technetium Tc 99m Pyrophosphate
• Technetium

MeSH terms

• Animals
• Antibodies, Monoclonal*
• Diphosphates*
• Dogs
• Female
• Indium Radioisotopes*
• Male
• Myocardial Infarction / diagnostic imaging
• Myocardial Reperfusion*
• Organometallic Compounds*
• Radionuclide Imaging
• Technetium*
• Technetium Tc 99m Pyrophosphate

Publication Types

• Comparative Study
• Journal Article
• Research Support, U.S. Gov't, P.H.S.

Grant support

• 17655/PHS HHS/United States
• CA 32845/CA/NCI NIH HHS/United States

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