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Müller-Felber W, Landgraf R, Wagner S, et al. Follow-up study of sensory-motor polyneuropathy in type 1 (insulin-dependent) diabetic subjects after simultaneous pancreas and kidney transplantation and after graft rejection. Diabetologia. 1991;34:S113-7doi: 10.1007/BF00587634.
Müller-Felber, W., Landgraf, R., Wagner, S., Mair, N., Nusser, J., Landgraf-Leurs, M. M., Abendroth, A., Illner, W. D., & Land, W. (1991). Follow-up study of sensory-motor polyneuropathy in type 1 (insulin-dependent) diabetic subjects after simultaneous pancreas and kidney transplantation and after graft rejection. Diabetologia, 34S113-7. https://doi.org/10.1007/BF00587634
Müller-Felber, W, et al. "Follow-up study of sensory-motor polyneuropathy in type 1 (insulin-dependent) diabetic subjects after simultaneous pancreas and kidney transplantation and after graft rejection." Diabetologia vol. 34 (1991): S113-7. doi: https://doi.org/10.1007/BF00587634
Müller-Felber W, Landgraf R, Wagner S, Mair N, Nusser J, Landgraf-Leurs MM, Abendroth A, Illner WD, Land W. Follow-up study of sensory-motor polyneuropathy in type 1 (insulin-dependent) diabetic subjects after simultaneous pancreas and kidney transplantation and after graft rejection. Diabetologia. 1991 Aug;34:S113-7. doi: 10.1007/BF00587634. PMID: 1936673.
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Diabetologia. 1991 Aug;34:S113-7. doi: 10.1007/BF00587634.

Follow-up study of sensory-motor polyneuropathy in type 1 (insulin-dependent) diabetic subjects after simultaneous pancreas and kidney transplantation and after graft rejection.

Diabetologia

W Müller-Felber, R Landgraf, S Wagner, N Mair, J Nusser, M M Landgraf-Leurs, A Abendroth, W D Illner, W Land

Affiliations

  1. Department of Internal Medicine Innenstadt, University of Munich, FRG.

PMID: 1936673 DOI: 10.1007/BF00587634

Abstract

The influence of successful simultaneous pancreas and kidney transplantation on peripheral polyneuropathy was investigated in 53 patients for a mean observation period of 40.3 months. Seventeen patients were followed-up for more than 3 years. Symptoms and signs were assessed every 6 months using a standard questionnaire, neurological examination and measurement of sensory and motor nerve conduction velocities. While symptoms of polyneuropathy improved (pain, paraesthesia, cramps, restless-legs) and nerve conduction velocity increased, there was no change of clinical signs (sensation, muscle-force, tendon-reflexes). Following kidney-graft-rejection there was a slight decrease of nerve conduction velocity during the first year, which was not statistically significant. Following pancreas-graft rejection there was no change of nerve conduction velocity during the first year. Comparing the maximum nerve conduction velocity of the patients with pancreas-graft-rejection to the nerve conduction velocities of these patients at the end of the study, there was a statistically significant decrease of 6.5 m/s. In conclusion, we believe that strict normalization of glucose metabolism alters the progressive course of diabetic polyneuropathy. It may be stabilized or partly reversed after successful grafting even in long-term diabetic patients.

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