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Schiffer AA, Pelle AJ, Smith OR, et al. Somatic versus cognitive symptoms of depression as predictors of all-cause mortality and health status in chronic heart failure. J Clin Psychiatry. 2009;70(12):1667-73doi: 10.4088/JCP.08m04609.
Schiffer, A. A., Pelle, A. J., Smith, O. R., Widdershoven, J. W., Hendriks, E. H., & Pedersen, S. S. (2009). Somatic versus cognitive symptoms of depression as predictors of all-cause mortality and health status in chronic heart failure. The Journal of clinical psychiatry, 70(12), 1667-73. https://doi.org/10.4088/JCP.08m04609
Schiffer, Angélique A, et al. "Somatic versus cognitive symptoms of depression as predictors of all-cause mortality and health status in chronic heart failure." The Journal of clinical psychiatry vol. 70,12 (2009): 1667-73. doi: https://doi.org/10.4088/JCP.08m04609
Schiffer AA, Pelle AJ, Smith OR, Widdershoven JW, Hendriks EH, Pedersen SS. Somatic versus cognitive symptoms of depression as predictors of all-cause mortality and health status in chronic heart failure. J Clin Psychiatry. 2009 Dec;70(12):1667-73. doi: 10.4088/JCP.08m04609. Epub 2009 Jul 28. PMID: 19646367.
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J Clin Psychiatry. 2009 Dec;70(12):1667-73. doi: 10.4088/JCP.08m04609. Epub 2009 Jul 28.

Somatic versus cognitive symptoms of depression as predictors of all-cause mortality and health status in chronic heart failure.

The Journal of clinical psychiatry

Angélique A Schiffer, Aline J Pelle, Otto R F Smith, Jos W Widdershoven, Eric H Hendriks, Susanne S Pedersen

Affiliations

  1. Department of Medical Psychology, TweeSteden Hospital, PO Box 90107, 5000 LA, Tilburg, the Netherlands. [email protected]

PMID: 19646367 DOI: 10.4088/JCP.08m04609

Abstract

OBJECTIVE: Depression is a predictor of adverse health outcomes in chronic heart failure (CHF), but it is not known whether specific symptoms drive this relationship. We examined the impact of somatic/affective, cognitive/affective, and total depressive symptoms on all-cause mortality and health status in CHF.

METHOD: Consecutive CHF outpatients (n = 366) completed the Beck Depression Inventory. The primary endpoint was all-cause mortality; the secondary endpoint was disease-specific health status, as measured by the Minnesota Living with Heart Failure Questionnaire (n = 285) at inclusion and 1-year follow-up. The study was conducted between October 2003 and March 2007.

RESULTS: There were 68 (18.6%) deaths (mean +/- SD follow-up, 37.2 +/- 10.6 months). Patients high on somatic/affective depressive symptoms had a greater incidence of mortality compared to patients low on somatic/affective depressive symptoms (31% vs 15%; hazard ratio [HR] = 2.3; 95% CI, 1.38-3.69; P = .001). There was no significant difference in the incidence of mortality between patients high versus low on cognitive/affective depressive symptoms (23% vs 18%; HR = 1.4; 95% CI, 0.80-2.40; P = .25), but there was a significant difference between patients high versus low on total depressive symptoms (24% vs 16%; HR = 1.6; 95% CI, 1.01-2.63; P < .05). After adjusting for demographic and clinical characteristics, we found that somatic/affective depressive symptoms predicted all-cause mortality (HR = 1.8; 95% CI, 1.03-3.07; P = .04), while cognitive/affective and total depressive symptoms did not. Both dimensions of depressive symptoms predicted disease-specific health status at 1 year.

CONCLUSIONS: Only somatic/affective depressive symptoms significantly predicted all-cause mortality in CHF. In the context of diagnosing and intervening, awareness of subtypes of depressive symptoms is important.

Copyright 2009 Physicians Postgraduate Press, Inc.

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