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Riddick LM, Garibaldi LR, Wang ME, et al. 3 alpha-Androstanediol glucuronide in premature and normal pubarche. J Clin Endocrinol Metab. 1991;72(1):46-50doi: 10.1210/jcem-72-1-46.
Riddick, L. M., Garibaldi, L. R., Wang, M. E., Senne, A. R., Klimah, P. E., Clark, A. T., Levine, L. S., Oberfield, S. E., & Pang, S. Y. (1991). 3 alpha-Androstanediol glucuronide in premature and normal pubarche. The Journal of clinical endocrinology and metabolism, 72(1), 46-50. https://doi.org/10.1210/jcem-72-1-46
Riddick, L M, et al. "3 alpha-Androstanediol glucuronide in premature and normal pubarche." The Journal of clinical endocrinology and metabolism vol. 72,1 (1991): 46-50. doi: https://doi.org/10.1210/jcem-72-1-46
Riddick LM, Garibaldi LR, Wang ME, Senne AR, Klimah PE, Clark AT, Levine LS, Oberfield SE, Pang SY. 3 alpha-Androstanediol glucuronide in premature and normal pubarche. J Clin Endocrinol Metab. 1991 Jan;72(1):46-50. doi: 10.1210/jcem-72-1-46. PMID: 1846006.
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J Clin Endocrinol Metab. 1991 Jan;72(1):46-50. doi: 10.1210/jcem-72-1-46.

3 alpha-Androstanediol glucuronide in premature and normal pubarche.

The Journal of clinical endocrinology and metabolism

L M Riddick, L R Garibaldi, M E Wang, A R Senne, P E Klimah, A T Clark, L S Levine, S E Oberfield, S Y Pang

Affiliations

  1. Department of Pediatrics, University of Illinois College of Medicine, Chicago 60612.

PMID: 1846006 DOI: 10.1210/jcem-72-1-46

Abstract

To investigate the role of adrenal androgens in 3 alpha-androstanediol glucuronide (3AG) production in childhood, we compared serum 3AG and androgen levels [dehydroepiandrosterone (DHEA), DHEA sulfate (DS), androstenedione (delta 4-A), and testosterone (T)] in 32 children with premature pubarche due to idiopathic premature adrenarche (IPA; n = 26), partial 21-hydroxylase deficiency (n = 2), or 3 beta-hydroxysteroid dehydrogenase deficiency (n = 4) with those in 36 normal prepubertal (18 males and 18 females) and 22 normal pubertal Tanner II-III subjects (10 males and 12 females). Serum 3AG (2.7 +/- 2.0 nmol/L) and all androgen concentrations in children with IPA were significantly higher (P less than 0.05-0.001) than those in normal prepubertal children (3AG, 0.8 +/- 0.5 nmol/L). Serum 3AG and androgen levels, except T, in all children with premature pubarche due to 21-hydroxylase deficiency or 3 beta-hydroxysteroid dehydrogenase deficiency were higher than those in the normal prepubertal children. Serum 3AG and all androgen levels in normal Tanner II-III male (3AG, 3.8 +/- 1.7 nmol/L) or female (3AG, 1.74 +/- 0.52 nmol/L) subjects were also significantly higher (P less than 0.05-0.001) than those in prepubertal children. Serum 3AG, DHEA, DS, and delta 4-A levels in children with IPA were similar to those in normal Tanner II-III females or males, but serum T in children with IPA (0.37 +/- 0.2 nmol/L) was significantly lower (P less than 0.05-0.001) than that in normal pubertal females (0.71 +/- 0.37 nmol/L) or males (4.5 +/- 2.6 nmol/L). In the combined group (n = 88), 3AG levels correlated better with serum DS (r = 0.7), DHEA (r = 0.6), and delta 4-A (r = 0.52), than with T (r = 0.31) levels. These data suggest that the weak adrenal androgens DS, DHEA, and delta 4-A contribute substantially to 3AG production in premature and normal pubarche.

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