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Cooper CE, White AR, Slocombe B. Activity of human extravascular temocillin concentrations simulated in an in-vitro kinetic model against beta-lactamase producing gram-negative bacilli. J Antimicrob Chemother. 1991;27(1):105-15doi: 10.1093/jac/27.1.105.
Cooper, C. E., White, A. R., & Slocombe, B. (1991). Activity of human extravascular temocillin concentrations simulated in an in-vitro kinetic model against beta-lactamase producing gram-negative bacilli. The Journal of antimicrobial chemotherapy, 27(1), 105-15. https://doi.org/10.1093/jac/27.1.105
Cooper, C E, et al. "Activity of human extravascular temocillin concentrations simulated in an in-vitro kinetic model against beta-lactamase producing gram-negative bacilli." The Journal of antimicrobial chemotherapy vol. 27,1 (1991): 105-15. doi: https://doi.org/10.1093/jac/27.1.105
Cooper CE, White AR, Slocombe B. Activity of human extravascular temocillin concentrations simulated in an in-vitro kinetic model against beta-lactamase producing gram-negative bacilli. J Antimicrob Chemother. 1991 Jan;27(1):105-15. doi: 10.1093/jac/27.1.105. PMID: 2050587.
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J Antimicrob Chemother. 1991 Jan;27(1):105-15. doi: 10.1093/jac/27.1.105.

Activity of human extravascular temocillin concentrations simulated in an in-vitro kinetic model against beta-lactamase producing gram-negative bacilli.

The Journal of antimicrobial chemotherapy

C E Cooper, A R White, B Slocombe

Affiliations

  1. SmithKline Beecham Pharmaceuticals, Betchworth, Surrey, UK.

PMID: 2050587 DOI: 10.1093/jac/27.1.105

Abstract

An in-vitro kinetic model was used to demonstrate the bactericidal activity of concentrations of temocillin achieved in extravascular body fluids following a 1 g intravenous dosage in man. Concentrations of temocillin attainable in peripheral lymph were bactericidal for ampicillin-resistant strains of Escherichia coli, Enterobacter cloacae and Klebsiella oxytoca. Likewise, concentrations of temocillin achieved in human blister fluid following a 12-hourly dosage regimen were bactericidal for cultures of Ent. cloacae and K. oxytoca which were resistant, respectively, to simulated blister fluid concentrations of cefotaxime and aztreonam. The bactericidal activity of extravascular concentrations of temocillin against these multiresistant, Gram-negative bacteria was a reflection of the beta-lactamase-stability and good pharmacokinetic properties of temocillin.

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