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Murai H, Takamura M, Maruyama M, et al. Altered firing pattern of single-unit muscle sympathetic nerve activity during handgrip exercise in chronic heart failure. J Physiol. 2009;587:2613-22doi: 10.1113/jphysiol.2009.172627.
Murai, H., Takamura, M., Maruyama, M., Nakano, M., Ikeda, T., Kobayashi, D., Otowa, K., Ootsuji, H., Okajima, M., Furusho, H., Takata, S., & Kaneko, S. (2009). Altered firing pattern of single-unit muscle sympathetic nerve activity during handgrip exercise in chronic heart failure. The Journal of physiology, 5872613-22. https://doi.org/10.1113/jphysiol.2009.172627
Murai, Hisayoshi, et al. "Altered firing pattern of single-unit muscle sympathetic nerve activity during handgrip exercise in chronic heart failure." The Journal of physiology vol. 587 (2009): 2613-22. doi: https://doi.org/10.1113/jphysiol.2009.172627
Murai H, Takamura M, Maruyama M, Nakano M, Ikeda T, Kobayashi D, Otowa K, Ootsuji H, Okajima M, Furusho H, Takata S, Kaneko S. Altered firing pattern of single-unit muscle sympathetic nerve activity during handgrip exercise in chronic heart failure. J Physiol. 2009 Jun 01;587:2613-22. doi: 10.1113/jphysiol.2009.172627. Epub 2009 Apr 29. PMID: 19403612; PMCID: PMC2714025.
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J Physiol. 2009 Jun 01;587:2613-22. doi: 10.1113/jphysiol.2009.172627. Epub 2009 Apr 29.

Altered firing pattern of single-unit muscle sympathetic nerve activity during handgrip exercise in chronic heart failure.

The Journal of physiology

Hisayoshi Murai, Masayuki Takamura, Michirou Maruyama, Manabu Nakano, Tatsunori Ikeda, Daisuke Kobayashi, Kan-ichi Otowa, Hiroshi Ootsuji, Masaki Okajima, Hiroshi Furusho, Shigeo Takata, Shuichi Kaneko

Affiliations

  1. Disease Control and Homeostasis, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan. [email protected]

PMID: 19403612 PMCID: PMC2714025 DOI: 10.1113/jphysiol.2009.172627

Abstract

Sympathetic activation in chronic heart failure (CHF) is greatly augmented at rest but the response to exercise remains controversial. We previously demonstrated that single-unit muscle sympathetic nerve activity (MSNA) provides a more detailed description of the sympathetic response to physiological stress than multi-unit nerve recordings. The purpose of this study was to determine whether the reflex response and discharge properties of single-unit MSNA are altered during handgrip exercise (HG, 30% of maximum voluntary contraction for 3 min) in CHF patients (New York Heart Association functional class II or III, n = 16) compared with age-matched healthy control subjects (n = 13). At rest, both single-unit and multi-unit indices of sympathetic outflow were augmented in CHF compared with controls (P < 0.05). However, the percentage of cardiac intervals that contained one, two, three or four single-unit spikes were not different between the groups. Compared to the control group, HG elicited a larger increase in multi-unit total MSNA (Delta1002 +/- 50 compared with Delta636 +/- 76 units min(-1), P < 0.05) and single-unit MSNA spike incidence (Delta27 +/- 5 compared with Delta8 +/- 2 spikes (100 heart beats)(-1)), P < 0.01) in the CHF patients. More importantly, the percentage of cardiac intervals that contained two or three single-unit spikes was increased (P < 0.05) during exercise in the CHF group only (Delta8 +/- 2% and Delta5 +/- 1% for two and three spikes, respectively). These results suggest that the larger multi-unit total MSNA response observed during HG in CHF is brought about in part by an increase in the probability of multiple firing of single-unit sympathetic neurones.

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