Stat Med. 1991 Jul;10(7):1115-22. doi: 10.1002/sim.4780100711.

Recovery of inter-block information in cross-over trials.

Statistics in medicine

E M Chi

PMID: 1876799 DOI: 10.1002/sim.4780100711

Abstract

For cross-over designs, we show that one can recover information on direct and/or residual treatment effects from an inter-block (patients as blocks) analysis as is done in an incomplete block design. By combining the intra- and inter-block estimates, we obtain the generalized least squares estimate. In analysing cross-over trials, we recommended this approach provided the between-patient variance component can be estimated efficiently.

Substances

• Amantadine

MeSH terms

• Amantadine / therapeutic use
• Analysis of Variance
• Asthma / drug therapy
• Clinical Trials as Topic / methods
• Data Interpretation, Statistical*
• Forced Expiratory Volume / drug effects
• Humans
• Hypertension / drug therapy
• Least-Squares Analysis
• Models, Statistical*
• Parkinson Disease / drug therapy

Publication Types

• Journal Article

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