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Schuler A, Spolarics Z, Lang CH, et al. Upregulation of glucose metabolism by granulocyte-monocyte colony-stimulating factor. Life Sci. 1991;49(12):899-906doi: 10.1016/0024-3205(91)90175-b.
Schuler, A., Spolarics, Z., Lang, C. H., Bagby, G. J., Nelson, S., & Spitzer, J. J. (1991). Upregulation of glucose metabolism by granulocyte-monocyte colony-stimulating factor. Life sciences, 49(12), 899-906. https://doi.org/10.1016/0024-3205(91)90175-b
Schuler, A, et al. "Upregulation of glucose metabolism by granulocyte-monocyte colony-stimulating factor." Life sciences vol. 49,12 (1991): 899-906. doi: https://doi.org/10.1016/0024-3205(91)90175-b
Schuler A, Spolarics Z, Lang CH, Bagby GJ, Nelson S, Spitzer JJ. Upregulation of glucose metabolism by granulocyte-monocyte colony-stimulating factor. Life Sci. 1991;49(12):899-906. doi: 10.1016/0024-3205(91)90175-b. PMID: 1875798.
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Elsevier Science

Life Sci. 1991;49(12):899-906. doi: 10.1016/0024-3205(91)90175-b.

Upregulation of glucose metabolism by granulocyte-monocyte colony-stimulating factor.

Life sciences

A Schuler, Z Spolarics, C H Lang, G J Bagby, S Nelson, J J Spitzer

Affiliations

  1. Department of Physiology, Louisiana State University Medical Center, New Orleans 70112.

PMID: 1875798 DOI: 10.1016/0024-3205(91)90175-b

Abstract

Alterations of glucose metabolism were investigated for 6 hours following an intraarterial injection of murine recombinant granulocyte-monocyte colony-stimulating factor (GM-CSF) (30 micrograms/kg body weight). GM-CSF resulted in a transient elevation of plasma glucose. The rate of whole body glucose appearance, as measured by infusion of [6-3H] glucose, was increased by about 10% between 0.5 and 3 hours following GM-CSF injection. In vivo glucose utilization of individual tissues was investigated by the tracer 2-deoxyglucose technique. At 30 min, GM-CSF increased glucose utilization by 80-90% in liver and lung, and 50-60% in skin and spleen. At 3 and 6 hours, glucose utilization by these tissues returned toward control levels except for lung. There was a 40-50% increase in glucose utilization by skeletal muscle 30 min after GM-CSF which was sustained for 6 hours. Glucose utilization of testis, ileum and kidney did not change significantly. Plasma concentrations of insulin, glucagon and tumor necrosis factor were not altered in response to GM-CSF. These findings indicate that some of the acute metabolic effects of a short-term administration of GM-CSF are observed in macrophage-rich tissues, and suggest that GM-CSF may be involved in the metabolic upregulation of immunologically active tissues.

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