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Zimber A, Zusman I, Bentor R, et al. Effects of lithocholic acid exposure throughout pregnancy on late prenatal and early postnatal development in rats. Teratology. 1991;43(4):355-61doi: 10.1002/tera.1420430410.
Zimber, A., Zusman, I., Bentor, R., & Pinus, H. (1991). Effects of lithocholic acid exposure throughout pregnancy on late prenatal and early postnatal development in rats. Teratology, 43(4), 355-61. https://doi.org/10.1002/tera.1420430410
Zimber, A, et al. "Effects of lithocholic acid exposure throughout pregnancy on late prenatal and early postnatal development in rats." Teratology vol. 43,4 (1991): 355-61. doi: https://doi.org/10.1002/tera.1420430410
Zimber A, Zusman I, Bentor R, Pinus H. Effects of lithocholic acid exposure throughout pregnancy on late prenatal and early postnatal development in rats. Teratology. 1991 Apr;43(4):355-61. doi: 10.1002/tera.1420430410. PMID: 2048044.
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Teratology. 1991 Apr;43(4):355-61. doi: 10.1002/tera.1420430410.

Effects of lithocholic acid exposure throughout pregnancy on late prenatal and early postnatal development in rats.

Teratology

A Zimber, I Zusman, R Bentor, H Pinus

Affiliations

  1. Department of Animal Science, Faculty of Agriculture, Hebrew University of Jerusalem, Rehovot, Israel.

PMID: 2048044 DOI: 10.1002/tera.1420430410

Abstract

The effects of lithocholic acid (LCA) on late prenatal and early postnatal development were studied. LCA was given in the diet (0.8% by weight) or administered in the drinking water (0.8%) throughout the entire period of pregnancy. The addition of LCA to the drinking water caused a significant reduction in the weight of 20-day-old fetuses as well as their placentas and livers. Feeding LCA to pregnant rats affected postnatal growth of the offspring: their weight was significantly lower than control values until 6 weeks of age. The pattern of postnatal growth was similar in the experimental and control rats. The retardation in growth and development of the offspring was accompanied by microscopic and biochemical changes in their livers.

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