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Mancinelli A, D'Aranno V, Stasi MA, et al. Effect of enantiomers of propranolol on desipramine-induced anti-immobility in the forced swimming test in the rat. Pharmacol Res. 1991;23(1):47-50doi: 10.1016/s1043-6618(05)80105-7.
Mancinelli, A., D'Aranno, V., Stasi, M. A., Lecci, A., Borsini, F., & Meli, A. (1991). Effect of enantiomers of propranolol on desipramine-induced anti-immobility in the forced swimming test in the rat. Pharmacological research, 23(1), 47-50. https://doi.org/10.1016/s1043-6618(05)80105-7
Mancinelli, A, et al. "Effect of enantiomers of propranolol on desipramine-induced anti-immobility in the forced swimming test in the rat." Pharmacological research vol. 23,1 (1991): 47-50. doi: https://doi.org/10.1016/s1043-6618(05)80105-7
Mancinelli A, D'Aranno V, Stasi MA, Lecci A, Borsini F, Meli A. Effect of enantiomers of propranolol on desipramine-induced anti-immobility in the forced swimming test in the rat. Pharmacol Res. 1991 Jan;23(1):47-50. doi: 10.1016/s1043-6618(05)80105-7. PMID: 2047359.
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Pharmacol Res. 1991 Jan;23(1):47-50. doi: 10.1016/s1043-6618(05)80105-7.

Effect of enantiomers of propranolol on desipramine-induced anti-immobility in the forced swimming test in the rat.

Pharmacological research

A Mancinelli, V D'Aranno, M A Stasi, A Lecci, F Borsini, A Meli

Affiliations

  1. Menarini Ricerche Sud, Roma, Italy.

PMID: 2047359 DOI: 10.1016/s1043-6618(05)80105-7

Abstract

The effect of d- and l-enantiomers of propranolol on desipramine-induced anti-immobility effects and on brain desipramine levels was studied in the rat. Intraperitoneal propranolol and desipramine were administered three times, 25, 6, 2 and 24, 5, 1 h respectively, before the test. It was found that l-propranolol but not d-propranolol, at the same doses (2.5 and 5 mg/kg), antagonized 20 mg/kg desipramine without altering desipramine brain levels. It is suggested that blockade of beta-adrenergic receptors rather than membrane-stabilizing or pharmacokinetic effects is responsible for the antagonism of propranolol toward desipramine.

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