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Cruz AT, Cazacu AC, McBride LJ, et al. Performance characteristics of a rapid immunochromatographic assay for detection of influenza virus in children during the 2003 to 2004 influenza season. Ann Emerg Med. 2005;47(3):250-4doi: 10.1016/j.annemergmed.2005.10.019.
Cruz, A. T., Cazacu, A. C., McBride, L. J., Greer, J. M., & Demmler, G. J. (2006). Performance characteristics of a rapid immunochromatographic assay for detection of influenza virus in children during the 2003 to 2004 influenza season. Annals of emergency medicine, 47(3), 250-4. https://doi.org/10.1016/j.annemergmed.2005.10.019
Cruz, Andrea T, et al. "Performance characteristics of a rapid immunochromatographic assay for detection of influenza virus in children during the 2003 to 2004 influenza season." Annals of emergency medicine vol. 47,3 (2006): 250-4. doi: https://doi.org/10.1016/j.annemergmed.2005.10.019
Cruz AT, Cazacu AC, McBride LJ, Greer JM, Demmler GJ. Performance characteristics of a rapid immunochromatographic assay for detection of influenza virus in children during the 2003 to 2004 influenza season. Ann Emerg Med. 2006 Mar;47(3):250-4. doi: 10.1016/j.annemergmed.2005.10.019. Epub 2005 Dec 20. PMID: 16492491.
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Ann Emerg Med. 2006 Mar;47(3):250-4. doi: 10.1016/j.annemergmed.2005.10.019. Epub 2005 Dec 20.

Performance characteristics of a rapid immunochromatographic assay for detection of influenza virus in children during the 2003 to 2004 influenza season.

Annals of emergency medicine

Andrea T Cruz, Andreea C Cazacu, Latresha J McBride, Jewel M Greer, Gail J Demmler

Affiliations

  1. Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. [email protected]

PMID: 16492491 DOI: 10.1016/j.annemergmed.2005.10.019

Abstract

STUDY OBJECTIVE: We evaluate the performance of a rapid assay (Binax NOW) for the detection of influenza A virus in children.

METHODS: The performance of an in vitro rapid immunochromatographic assay for detection of influenza A virus was compared to viral culture in 4,383 consecutive respiratory specimens received during the 2003 to 2004 season, which included an influenza A epidemic in October and November of 2003.

RESULTS: The overall test sensitivity was 61.6% (95% confidence interval [CI] 60.3% to 63.2%) and specificity was 95.8% (95% CI 95.1% to 96.3%). In preplanned subset analyses, we found the test more sensitive in infants aged 90 days or younger (sensitivity 70.3%; specificity 96.6%) and less specific during the epidemic (sensitivity 61.7%; specificity 90.4%).

CONCLUSION: This rapid assay was highly specific for detecting influenza A in children and thus appears useful for confirming this infection. Because of its limited sensitivity, however, a negative test cannot rule out influenza A.

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