Biol Psychiatry. 1991 Sep 01;30(5):475-82. doi: 10.1016/0006-3223(91)90309-a.

Plasma free homovanillic acid (HVA) as a predictor of clinical response in acute psychosis.

Biological psychiatry

C M Mazure, J C Nelson, P I Jatlow, M B Bowers

PMID: 1932395 DOI: 10.1016/0006-3223(91)90309-a

Abstract

The relationship of plasma free homovanillic acid (HVA) and methoxyhydroxyphenylglycol (MHPG) to early clinical response was prospectively studied in a new series of acutely psychotic inpatients given a fixed dose of perphenazine elixir for 10 days. Elevated pretreatment plasma HVA but not MHPG was significantly associated with good response. Change in HVA was correlated with a favorable response and a significant decline in MHPG was found in responders. Results suggest that HVA can provide a useful clinical predictor of response, and that both dopamine metabolism and noradrenergic functioning, as measured by plasma HVA and MHPG, are reduced in effective neuroleptic treatment.

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Substances

• Methoxyhydroxyphenylglycol
• Perphenazine
• Homovanillic Acid

MeSH terms

• Acute Disease
• Adolescent
• Adult
• Bipolar Disorder / blood
• Bipolar Disorder / drug therapy
• Bipolar Disorder / psychology
• Chromatography, High Pressure Liquid
• Depressive Disorder / blood
• Depressive Disorder / drug therapy
• Depressive Disorder / psychology
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Female
• Follow-Up Studies
• Homovanillic Acid / blood
• Humans
• Male
• Methoxyhydroxyphenylglycol / blood
• Middle Aged
• Perphenazine / administration & dosage
• Prognosis
• Prospective Studies
• Psychiatric Status Rating Scales*
• Psychotic Disorders / blood
• Psychotic Disorders / drug therapy
• Psychotic Disorders / psychology
• Schizophrenia / blood
• Schizophrenia / drug therapy
• Schizophrenic Psychology

Publication Types

• Journal Article

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