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Karlik S, Florio E, Grant CW. Comparative evaluation of two membrane-based liposomal MRI contrast agents. Magn Reson Med. 1991;19(1):56-66doi: 10.1002/mrm.1910190106.
Karlik, S., Florio, E., & Grant, C. W. (1991). Comparative evaluation of two membrane-based liposomal MRI contrast agents. Magnetic resonance in medicine, 19(1), 56-66. https://doi.org/10.1002/mrm.1910190106
Karlik, S, et al. "Comparative evaluation of two membrane-based liposomal MRI contrast agents." Magnetic resonance in medicine vol. 19,1 (1991): 56-66. doi: https://doi.org/10.1002/mrm.1910190106
Karlik S, Florio E, Grant CW. Comparative evaluation of two membrane-based liposomal MRI contrast agents. Magn Reson Med. 1991 May;19(1):56-66. doi: 10.1002/mrm.1910190106. PMID: 2046538.
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Magn Reson Med. 1991 May;19(1):56-66. doi: 10.1002/mrm.1910190106.

Comparative evaluation of two membrane-based liposomal MRI contrast agents.

Magnetic resonance in medicine

S Karlik, E Florio, C W Grant

Affiliations

  1. Department of Diagnostic Radiology, University Hospital, London, Canada.

PMID: 2046538 DOI: 10.1002/mrm.1910190106

Abstract

Two phospholipids--one bearing a nitroxide free radical covalently attached to its polar headgroup, and the other bearing a similarly attached chelating agent with bound gadolinium--were compared in vivo as liposomal contrast agents for MR imaging. In each case the phospholipid contrast agent was incorporated into the membranes of sonicated unilamellar vesicles. The agent with bound gadolinium proved to be considerably more potent at highlighting regions of liposome biodistribution than did its spin-labelled analogue. Injected intramuscularly into rats, the spin-label liposomes produced local tissue contrast that persisted for 1 h; while under similar conditions, the liposomal gadolinium persisted for over 24 h. By comparison, water-soluble, nonliposomal DTPA-Gd3+ (dimeglumine), was rapidly cleared from the same intramuscular sites--appearing in kidney bladder within 15 min of injection. When delivered intravenously, maximum effect from both liposomal agents was observed in liver and spleen within 1-2 h, although the spin-label agent produced only marginal contrast. The concomitant use of fat suppression proved a valuable adjunct to liposomal contrast for imaging organs of the reticuloendothelial system.

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