Burns. 1991 Aug;17(4):279-81. doi: 10.1016/0305-4179(91)90039-j.

Insulin-like growth factor 1 (IGF-1) in burn patients.

Burns : journal of the International Society for Burn Injuries

S Møller, M Jensen, P Svensson, N E Skakkebaek

PMID: 1930660 DOI: 10.1016/0305-4179(91)90039-j

Abstract

Variations in growth factor IGF-1 levels during wound healing were assessed in 23 patients with burns of varying extent and severity. The patients were followed during the postburn period and the IGF-1 levels were regularly measured by radioimmunoassay. All patients with large burns had reduced IGF-1 levels which correlated with the surface area of burn. The most plausible reason for the suppressed IGF-1 level in these patients may be diffusion from the burned skin as we have found a strong correlation between IGF-1 and serum albumin. The reduced IGF-1 levels may contribute to impaired wound healing in these patients.

Cited by

Substances

• Serum Albumin
• Insulin-Like Growth Factor I

MeSH terms

• Adult
• Body Surface Area
• Burns / blood
• Burns / physiopathology
• Burns / surgery
• Female
• Humans
• Insulin-Like Growth Factor I / analysis
• Male
• Middle Aged
• Radioimmunoassay
• Serum Albumin / analysis
• Wound Healing / physiology

Publication Types

• Journal Article
• Research Support, Non-U.S. Gov't

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