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Bagby GJ, Plessala KJ, Wilson LA, et al. Divergent efficacy of antibody to tumor necrosis factor-alpha in intravascular and peritonitis models of sepsis. J Infect Dis. 1991;163(1):83-8doi: 10.1093/infdis/163.1.83.
Bagby, G. J., Plessala, K. J., Wilson, L. A., Thompson, J. J., & Nelson, S. (1991). Divergent efficacy of antibody to tumor necrosis factor-alpha in intravascular and peritonitis models of sepsis. The Journal of infectious diseases, 163(1), 83-8. https://doi.org/10.1093/infdis/163.1.83
Bagby, G J, et al. "Divergent efficacy of antibody to tumor necrosis factor-alpha in intravascular and peritonitis models of sepsis." The Journal of infectious diseases vol. 163,1 (1991): 83-8. doi: https://doi.org/10.1093/infdis/163.1.83
Bagby GJ, Plessala KJ, Wilson LA, Thompson JJ, Nelson S. Divergent efficacy of antibody to tumor necrosis factor-alpha in intravascular and peritonitis models of sepsis. J Infect Dis. 1991 Jan;163(1):83-8. doi: 10.1093/infdis/163.1.83. PMID: 1984480.
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J Infect Dis. 1991 Jan;163(1):83-8. doi: 10.1093/infdis/163.1.83.

Divergent efficacy of antibody to tumor necrosis factor-alpha in intravascular and peritonitis models of sepsis.

The Journal of infectious diseases

G J Bagby, K J Plessala, L A Wilson, J J Thompson, S Nelson

Affiliations

  1. Department of Physiology, Louisiana State University Medical Center, New Orleans 70112.

PMID: 1984480 DOI: 10.1093/infdis/163.1.83

Abstract

The role of tumor necrosis factor-alpha (TNF alpha) in the lethal consequences of intravascular lipopolysaccharide (LPS) or Escherichia coli sepsis was compared with that in bacterial peritonitis. Intravenous administration of E. coli LPS or E. coli (live or dead) resulted in large transient increases in serum TNF alpha levels, peaking at 90 min at 10,000-30,000 units/ml. In contrast, the serum TNF alpha response following the induction of bacterial peritonitis was substantially less, peaking at 200-500 units/ml. Sterile peritonitis (essentially nonlethal) and bacterial peritonitis (greater than 60% lethal) elevated TNF alpha levels to 1000-2000 units/lavage within the peritoneal cavity 2 h after challenge. Passive immunization with neutralizing goat anti-TNF alpha IgG improved survival from 8% to 75% in rats administered LPS intravenously but was completely ineffective in protecting rats from lethal E. coli peritonitis. Thus significant differences exist in the role TNF alpha plays in systemic intravascular models of sepsis and bacterial peritonitis.

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