Display options
Cite
Raper RF, Sibbald WJ, Hobson J, et al. Effect of PGE1 on altered distribution of regional blood flows in hyperdynamic sepsis. Chest. 1991;100(6):1703-11doi: 10.1378/chest.100.6.1703.
Raper, R. F., Sibbald, W. J., Hobson, J., & Rutledge, F. S. (1991). Effect of PGE1 on altered distribution of regional blood flows in hyperdynamic sepsis. Chest, 100(6), 1703-11. https://doi.org/10.1378/chest.100.6.1703
Raper, R F, et al. "Effect of PGE1 on altered distribution of regional blood flows in hyperdynamic sepsis." Chest vol. 100,6 (1991): 1703-11. doi: https://doi.org/10.1378/chest.100.6.1703
Raper RF, Sibbald WJ, Hobson J, Rutledge FS. Effect of PGE1 on altered distribution of regional blood flows in hyperdynamic sepsis. Chest. 1991 Dec;100(6):1703-11. doi: 10.1378/chest.100.6.1703. PMID: 1959417.
Copy Download .nbib Format: NLM
Share it on
Full text links
Elsevier Science

Chest. 1991 Dec;100(6):1703-11. doi: 10.1378/chest.100.6.1703.

Effect of PGE1 on altered distribution of regional blood flows in hyperdynamic sepsis.

Chest

R F Raper, W J Sibbald, J Hobson, F S Rutledge

Affiliations

  1. Richard Ivey Critical Care Trauma Centre, Victoria Hospital, London, Ontario, Canada.

PMID: 1959417 DOI: 10.1378/chest.100.6.1703

Abstract

Since the sepsis syndrome is associated with depressed vascular reactivity, it may be incorrect to assume that pharmacologically mediated changes in cardiac output will be proportionately distributed at the regional level of the circulation. We examined the effect of hyperdynamic sepsis and the concurrent administration of the vasodilatory prostaglandin (PGE1) on the regional distribution of blood flows (Q) in unanesthetized sheep rendered septic by cecal ligation and perforation. Systemic Q progressively increased throughout a 48-h study period after cecal ligation and perforation. Simultaneously, organ Q, measured by the radioactive microsphere technique, was depressed to the pancreas, but increased to the heart, gallbladder, brain, and colon; the increased Q to both heart and gallbladder was greater than the simultaneous increase in systemic Q in this septic study. With the infusion of PGE1 (1 microgram/kg/min), mean arterial perfusing pressures fell, while the cardiac index increased further over that recorded during the 48-h septic study. Despite this depression in arterial pressures, the only significant effect of PGE1 on the interorgan distribution of Q was in the renal circulation, where it was demonstrated that kidney Q fell. We conclude that (1) hyperdynamic and normotensive sepsis exerted nonhomogeneous effects on the distribution of organ Q, and (2) an increased systemic Q during PGE1 infusion was proportionately distributed to all organs, except the kidneys, where Q paradoxically fell. The latter finding suggests that the regulation of kidney Q may be depressed across the normal range of arterial perfusing pressures in the sepsis syndrome. Further investigation is essential to understand the effect of clinical interventions on the control of tissue O2 flux at both the regional and microregional levels of the circulation.

Cited by

Substances

MeSH terms

Publication Types

LinkOut - more resources