Display options
Cite
Heuman DM, Mills AS, McCall J, et al. Conjugates of ursodeoxycholate protect against cholestasis and hepatocellular necrosis caused by more hydrophobic bile salts. In vivo studies in the rat. Gastroenterology. 1991;100(1):203-11doi: 10.1016/0016-5085(91)90602-h.
Heuman, D. M., Mills, A. S., McCall, J., Hylemon, P. B., Pandak, W. M., & Vlahcevic, Z. R. (1991). Conjugates of ursodeoxycholate protect against cholestasis and hepatocellular necrosis caused by more hydrophobic bile salts. In vivo studies in the rat. Gastroenterology, 100(1), 203-11. https://doi.org/10.1016/0016-5085(91)90602-h
Heuman, D M, et al. "Conjugates of ursodeoxycholate protect against cholestasis and hepatocellular necrosis caused by more hydrophobic bile salts. In vivo studies in the rat." Gastroenterology vol. 100,1 (1991): 203-11. doi: https://doi.org/10.1016/0016-5085(91)90602-h
Heuman DM, Mills AS, McCall J, Hylemon PB, Pandak WM, Vlahcevic ZR. Conjugates of ursodeoxycholate protect against cholestasis and hepatocellular necrosis caused by more hydrophobic bile salts. In vivo studies in the rat. Gastroenterology. 1991 Jan;100(1):203-11. doi: 10.1016/0016-5085(91)90602-h. PMID: 1983822.
Copy Download .nbib Format: NLM
Share it on
Full text links
Elsevier Science

Gastroenterology. 1991 Jan;100(1):203-11. doi: 10.1016/0016-5085(91)90602-h.

Conjugates of ursodeoxycholate protect against cholestasis and hepatocellular necrosis caused by more hydrophobic bile salts. In vivo studies in the rat.

Gastroenterology

D M Heuman, A S Mills, J McCall, P B Hylemon, W M Pandak, Z R Vlahcevic

Affiliations

  1. Department of Medicine, Medical College of Virginia, Richmond.

PMID: 1983822 DOI: 10.1016/0016-5085(91)90602-h

Abstract

The protective effect of ursodeoxycholate conjugates against bile salt hepatotoxicity was studied in chronic bile fistula rats. Taurochenodeoxycholate or taurodeoxycholate, infused intraduodenally at 24 or 16 mumols/100 g rat per hour, respectively, caused cholestasis and severe hepatocellular necrosis within 8 hours. In contrast, tauroursodeoxycholate or taurocholate at 48 mumols/100 g rat per hour were choleretic. Tauroursodeoxycholate was not hepatotoxic, whereas taurocholate produced moderate hepatocellular necrosis. Simultaneous infusion of tauroursodeoxycholate to rats receiving taurochenoxycholate or taurodeoxycholate preserved bile flow and ameliorated hepatic injury in a dose-dependent manner. Tauroursodeoxycholate protected equally by intravenous and intraduodenal routes. Intravenous glycoursodeoxycholate also was protective. The hydrophobicity index of infused bile salts correlated well with their toxicity. Concurrent administration of ursodeoxycholate conjugates did not reduce biliary recovery of intraduodenally infused [24-14C]-taurocholate. Biliary alkaline phosphatase secretion was stimulated by infusion of taurocholate, taurodeoxycholate, or taurochenodeoxycholate; simultaneous infusion of ursodeoxycholate conjugates failed to prevent this increase. We conclude that ursodeoxycholate counteracts hepatoxicity of more hydrophobic bile salts via a direct effect at the level of the liver.

Similar articles

Cited by

Substances

MeSH terms

Publication Types

LinkOut - more resources