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Walsh JH, Karnes WE, Cuttitta F, et al. Autocrine growth factors and solid tumor malignancy. West J Med. 1991;155(2):152-63
Walsh, J. H., Karnes, W. E., Cuttitta, F., & Walker, A. (1991). Autocrine growth factors and solid tumor malignancy. The Western journal of medicine, 155(2), 152-63.
Walsh, J H, et al. "Autocrine growth factors and solid tumor malignancy." The Western journal of medicine vol. 155,2 (1991): 152-63.
Walsh JH, Karnes WE, Cuttitta F, Walker A. Autocrine growth factors and solid tumor malignancy. West J Med. 1991 Aug;155(2):152-63. PMID: 1926844; PMCID: PMC1002946.
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West J Med. 1991 Aug;155(2):152-63.

Autocrine growth factors and solid tumor malignancy.

The Western journal of medicine

J H Walsh, W E Karnes, F Cuttitta, A Walker

Affiliations

  1. CURE/Wadsworth Department of Veterans Affairs, Los Angeles, CA 90073.

PMID: 1926844 PMCID: PMC1002946
Free PMC Article

Abstract

The ability of malignant cells to escape the constraint that normally regulate cell growth and differentiation has been a primary focus of attention for investigators of cancer cell biology. An outcome of this attention has been the discovery that the protein products of oncogenes play a role in the activation of growth signal pathways. A second outcome, possibly related to abnormal oncogene expression, has been the discovery that malignant cells frequently show an ability to regulate their own growth by the release of autocrine growth modulatory substances. Most important, the growth of certain malignant cell types has been shown to depend on autocrine growth circuits. A malignant tumor whose continued growth depends on the release of an autocrine growth factor may be vulnerable to treatment with specific receptor antagonists or immunoneutralizing antibodies designed to break the autocrine circuit. Information is rapidly emerging concerning autocrine growth factors in selected human solid tissue malignancy.

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