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Srinivasan M, Irving BA, Dhatariya K, et al. Effect of dehydroepiandrosterone replacement on lipoprotein profile in hypoadrenal women. J Clin Endocrinol Metab. 2008;94(3):761-4doi: 10.1210/jc.2008-1774.
Srinivasan, M., Irving, B. A., Dhatariya, K., Klaus, K. A., Hartman, S. J., McConnell, J. P., & Nair, K. S. (2009). Effect of dehydroepiandrosterone replacement on lipoprotein profile in hypoadrenal women. The Journal of clinical endocrinology and metabolism, 94(3), 761-4. https://doi.org/10.1210/jc.2008-1774
Srinivasan, Manivannan, et al. "Effect of dehydroepiandrosterone replacement on lipoprotein profile in hypoadrenal women." The Journal of clinical endocrinology and metabolism vol. 94,3 (2009): 761-4. doi: https://doi.org/10.1210/jc.2008-1774
Srinivasan M, Irving BA, Dhatariya K, Klaus KA, Hartman SJ, McConnell JP, Nair KS. Effect of dehydroepiandrosterone replacement on lipoprotein profile in hypoadrenal women. J Clin Endocrinol Metab. 2009 Mar;94(3):761-4. doi: 10.1210/jc.2008-1774. Epub 2008 Dec 09. PMID: 19066301; PMCID: PMC2681274.
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J Clin Endocrinol Metab. 2009 Mar;94(3):761-4. doi: 10.1210/jc.2008-1774. Epub 2008 Dec 09.

Effect of dehydroepiandrosterone replacement on lipoprotein profile in hypoadrenal women.

The Journal of clinical endocrinology and metabolism

Manivannan Srinivasan, Brian A Irving, Ketan Dhatariya, Katherine A Klaus, Stacy J Hartman, Joseph P McConnell, K Sreekumaran Nair

Affiliations

  1. Division of Endocrinology, Endocrine Research Unit, Mayo Clinic and Mayo Foundation,, Rochester, Minnesota 55905, USA.

PMID: 19066301 PMCID: PMC2681274 DOI: 10.1210/jc.2008-1774

Abstract

CONTEXT: Levels of dehydroepiandrosterone (DHEA) and its sulfate form (DHEAS) are inversely associated with cardiovascular mortality in men but not women. Very little evidence is available on the impact of DHEA administration on lipoprotein profile in women. DHEAS levels are very low/undetectable in hypoadrenal women.

OBJECTIVE: The objective of the study was to determine the impact of DHEA replacement on lipoprotein profile in hypoadrenal women.

DESIGN AND SETTING: A double-blind, randomized, placebo-controlled, cross-over design study was conducted at the Mayo Clinic.

PARTICIPANTS: Thirty-three hypoadrenal Caucasian women (mean +/- sd; age 50.3 +/- 15.2 yr, body mass index 26.6 +/- 4.4 kg/m(2)) took part in the study.

INTERVENTION: Study participants were assigned to receive either a placebo or 50 mg/d of DHEA for 3 months each. Lipid levels and lipoprotein profile were analyzed using the Lipo Science Lipoprotein nuclear magnetic resonance system.

MAIN OUTCOME MEASURES: Changes in various lipoprotein sizes and levels were measured.

RESULTS: The DHEA period had higher plasma DHEAS levels than during placebo (<0.3 +/- 0.0 vs. 3.5 +/- 1.3 nmol/liter, P < 0.001). DHEA replacement significantly reduced total cholesterol (20.0 vs. -22, P = 0.02) and high-density lipoprotein (HDL) levels (2.0 vs. -6.0, P = 0.006) and tends to reduce triglyceride and total low-density lipoprotein levels. Although, DHEA replacement had no effect on low-density lipoprotein particle size, it significantly reduced larger HDL particles and to modest extent small HDL particles.

CONCLUSIONS: Our study findings showed that oral DHEA administration in hypoadrenal women results in an unfavorable lipoprotein profile. The results warrant long-term studies to determine the impact of DHEA replacement on cardiovascular risk.

References

  1. Circulation. 2002 Dec 17;106(25):3143-421 - PubMed
  2. N Engl J Med. 1986 Dec 11;315(24):1519-24 - PubMed
  3. FASEB J. 1992 Sep;6(12):3073-5 - PubMed
  4. J Clin Endocrinol Metab. 1990 Sep;71(3):696-704 - PubMed
  5. Diabetes. 2005 Mar;54(3):765-9 - PubMed
  6. Circulation. 1997 Apr 15;95(8):2022-6 - PubMed
  7. Front Biosci. 2001 Mar 01;6:D355-65 - PubMed
  8. N Engl J Med. 2006 Oct 19;355(16):1647-59 - PubMed
  9. Physiol Res. 2000;49 Suppl 1:S43-56 - PubMed
  10. J Am Coll Cardiol. 2008 Feb 12;51(6):634-42 - PubMed
  11. Circulation. 1994 Jul;90(1):42-9 - PubMed
  12. Maturitas. 1980 Dec;2(4):301-9 - PubMed
  13. Arterioscler Thromb. 1991 Jan-Feb;11(1):174-82 - PubMed
  14. J Am Coll Cardiol. 2003 Dec 3;42(11):1967-74 - PubMed
  15. J Clin Invest. 1988 Aug;82(2):712-20 - PubMed
  16. J Clin Endocrinol Metab. 1994 Jun;78(6):1360-7 - PubMed
  17. Mayo Clin Proc. 2003 Oct;78(10):1257-73 - PubMed

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