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Guo X, Tang XC. Lappaconitine and N-deacetyllappaconitine potentiate footshock-induced analgesia in rats. Life Sci. 1991;48(14):1365-70doi: 10.1016/0024-3205(91)90432-b.
Guo, X., & Tang, X. C. (1991). Lappaconitine and N-deacetyllappaconitine potentiate footshock-induced analgesia in rats. Life sciences, 48(14), 1365-70. https://doi.org/10.1016/0024-3205(91)90432-b
Guo, X, and Tang, X C. "Lappaconitine and N-deacetyllappaconitine potentiate footshock-induced analgesia in rats." Life sciences vol. 48,14 (1991): 1365-70. doi: https://doi.org/10.1016/0024-3205(91)90432-b
Guo X, Tang XC. Lappaconitine and N-deacetyllappaconitine potentiate footshock-induced analgesia in rats. Life Sci. 1991;48(14):1365-70. doi: 10.1016/0024-3205(91)90432-b. PMID: 2008153.
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Elsevier Science

Life Sci. 1991;48(14):1365-70. doi: 10.1016/0024-3205(91)90432-b.

Lappaconitine and N-deacetyllappaconitine potentiate footshock-induced analgesia in rats.

Life sciences

X Guo, X C Tang

Affiliations

  1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai.

PMID: 2008153 DOI: 10.1016/0024-3205(91)90432-b

Abstract

The effects of lappaconitine (LA) and N-deacetyllappaconitine (DLA) on footshock-induced analgesia (FSIA) were studied by the rat tail flick test. Rats subjected to 90 s nonescaping footshock had a significant increase in tail flick latency. Naloxone (4 micrograms, i.c.v.) partially antagonized the FSIA. After 5 consecutive exposures to footshock, rats developed a complete tolerance to the FSIA. The rats tolerant to FSIA showed a cross-tolerance to morphine- but not LA- and DLA-induced analgesia. Administrations of subanalgesic doses of LA and DLA potentiated the FSIA in both intact and adrenalectomized rats.

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